Loss of expression of α4β7 integrin and L-selectin is associated with high-grade progression of low-grade MALT lymphoma

Y. X. Liu, Tadashi Yoshino, N. Ohara, Takashi Oka, Z. S. Jin, K. Hayashi, T. Akagi

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Expression of adhesion molecule in low-grade B-cell mucosa-associated lymphoid tissue (MALT) lymphoma of the gastrointestinal tract has been reported in recent years, but these reports have primarily focused on low-grade gastrointestinal MALT lymphoma. In this study, we examined the lymphocytic homing receptor α4β7 integrin, L-selectin, and VLA-4 and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in low-grade lymphoma of the gastrointestinal tract and other organs such as the ocular adnexa and thyroid. We also observed changes in the expression pattern associated with high-grade transformation. Neoplastic cells in the gastrointestinal low-grade lymphoma and the low-grade component of high-grade MALT lymphoma were found to be α4β7 integrin+, L-selectin+, whereas the gastrointestinal high-grade component and diffuse large B-cell lymphoma were found to be α4β7 integrin-, L-selectin-. High endothelial venules in the gastric MALT lymphomas expressed MAdCAM-1. In the ocular adnexa low-grade MALT lymphoma, most cases were α4β7 integrin-, L-selectin+; and in the thyroid, most cases of both low- and high-grade MALT lymphoma were α4β7 integrin-, L-selectin-. These findings show that α4β7 integrin and L-selectin may play an important role in the lymphocyte homing of gastrointestinal low-grade MALT lymphoma and in the loss of α4β7 integrin expression throughout the course of high-grade progression.

Original languageEnglish
Pages (from-to)798-805
Number of pages8
JournalModern Pathology
Volume14
Issue number8
DOIs
Publication statusPublished - 2001

Fingerprint

L-Selectin
Marginal Zone B-Cell Lymphoma
Integrins
Non-Hodgkin's Lymphoma
Cell Adhesion Molecules
Gastrointestinal Tract
Thyroid Gland
Integrin alpha4beta1
Venules
Lymphoma, Large B-Cell, Diffuse
B-Cell Lymphoma
Gastric Mucosa
Lymphocytes

Keywords

  • α4β7 integrin
  • Adhesion molecule
  • L-selectin
  • MALT lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Loss of expression of α4β7 integrin and L-selectin is associated with high-grade progression of low-grade MALT lymphoma. / Liu, Y. X.; Yoshino, Tadashi; Ohara, N.; Oka, Takashi; Jin, Z. S.; Hayashi, K.; Akagi, T.

In: Modern Pathology, Vol. 14, No. 8, 2001, p. 798-805.

Research output: Contribution to journalArticle

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