Loss of basement membrane heparan sulfate expression is associated with tumor progression in endometrial cancer

Hasengaowa, J. Kodama, T. Kusumoto, Y. Shinyo, N. Seki, K. Nakamura, A. Hongo, Y. Hiramatsu

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Perlecan is a major heparan sulfate proteoglycan (HPSG) of the basement membrane (BM) and binds to various cytokines and growth factors via its heparan sulfate glycosaminoglycan (HS-GAG) chains. The aim of this study was to investigate BM HS-GAG expression in endometrial cancers. We investigated the expression of BM HS-GAG by immunohistochemistry in 109 endometrial cancers and analyzed correlations with various clinicopathological features. The HS-GAG expression index was significantly lower in cases of advanced stage, high-grade, deep myometrial invasion, positive peritoneal cytology, lymph vascular space invasion and lymph node metastasis. There was no association between HS-GAG expression status and patient outcome. Decreased HS-GAG expression of BM is associated with tumor progression, but is not be a useful prognostic factor in patients presenting with endometrial cancer.

Original languageEnglish
Pages (from-to)403-406
Number of pages4
JournalEuropean Journal of Gynaecological Oncology
Volume26
Issue number4
Publication statusPublished - 2005

Keywords

  • Basement membrane
  • Endometrial cancer
  • Heparan sulfate

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynaecology

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