Loss of basement membrane heparan sulfate expression is associated with tumor progression in endometrial cancer

Hasengaowa; J. Kodama; Tomoyuki Kusumoto; Y. Shinyo; Noriko Seki; K. Nakamura; A. Hongo; Yuji Hiramatsu

Loss of basement membrane heparan sulfate expression is associated with tumor progression in endometrial cancer

Hasengaowa, J. Kodama, Tomoyuki Kusumoto, Y. Shinyo, Noriko Seki, K. Nakamura, A. Hongo, Yuji Hiramatsu

Research output: Contribution to journal › Article › peer-review

Abstract

Perlecan is a major heparan sulfate proteoglycan (HPSG) of the basement membrane (BM) and binds to various cytokines and growth factors via its heparan sulfate glycosaminoglycan (HS-GAG) chains. The aim of this study was to investigate BM HS-GAG expression in endometrial cancers. We investigated the expression of BM HS-GAG by immunohistochemistry in 109 endometrial cancers and analyzed correlations with various clinicopathological features. The HS-GAG expression index was significantly lower in cases of advanced stage, high-grade, deep myometrial invasion, positive peritoneal cytology, lymph vascular space invasion and lymph node metastasis. There was no association between HS-GAG expression status and patient outcome. Decreased HS-GAG expression of BM is associated with tumor progression, but is not be a useful prognostic factor in patients presenting with endometrial cancer.

Original language	English
Pages (from-to)	403-406
Number of pages	4
Journal	European Journal of Gynaecological Oncology
Volume	26
Issue number	4
Publication status	Published - 2005

Keywords

Basement membrane
Endometrial cancer
Heparan sulfate

ASJC Scopus subject areas

Oncology
Obstetrics and Gynaecology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Loss of basement membrane heparan sulfate expression is associated with tumor progression in endometrial cancer",

abstract = "Perlecan is a major heparan sulfate proteoglycan (HPSG) of the basement membrane (BM) and binds to various cytokines and growth factors via its heparan sulfate glycosaminoglycan (HS-GAG) chains. The aim of this study was to investigate BM HS-GAG expression in endometrial cancers. We investigated the expression of BM HS-GAG by immunohistochemistry in 109 endometrial cancers and analyzed correlations with various clinicopathological features. The HS-GAG expression index was significantly lower in cases of advanced stage, high-grade, deep myometrial invasion, positive peritoneal cytology, lymph vascular space invasion and lymph node metastasis. There was no association between HS-GAG expression status and patient outcome. Decreased HS-GAG expression of BM is associated with tumor progression, but is not be a useful prognostic factor in patients presenting with endometrial cancer.",

keywords = "Basement membrane, Endometrial cancer, Heparan sulfate",

author = "Hasengaowa and J. Kodama and Tomoyuki Kusumoto and Y. Shinyo and Noriko Seki and K. Nakamura and A. Hongo and Yuji Hiramatsu",

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language = "English",

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TY - JOUR

T1 - Loss of basement membrane heparan sulfate expression is associated with tumor progression in endometrial cancer

AU - Hasengaowa,

AU - Kodama, J.

AU - Kusumoto, Tomoyuki

AU - Shinyo, Y.

AU - Seki, Noriko

AU - Nakamura, K.

AU - Hongo, A.

AU - Hiramatsu, Yuji

PY - 2005

Y1 - 2005

N2 - Perlecan is a major heparan sulfate proteoglycan (HPSG) of the basement membrane (BM) and binds to various cytokines and growth factors via its heparan sulfate glycosaminoglycan (HS-GAG) chains. The aim of this study was to investigate BM HS-GAG expression in endometrial cancers. We investigated the expression of BM HS-GAG by immunohistochemistry in 109 endometrial cancers and analyzed correlations with various clinicopathological features. The HS-GAG expression index was significantly lower in cases of advanced stage, high-grade, deep myometrial invasion, positive peritoneal cytology, lymph vascular space invasion and lymph node metastasis. There was no association between HS-GAG expression status and patient outcome. Decreased HS-GAG expression of BM is associated with tumor progression, but is not be a useful prognostic factor in patients presenting with endometrial cancer.

AB - Perlecan is a major heparan sulfate proteoglycan (HPSG) of the basement membrane (BM) and binds to various cytokines and growth factors via its heparan sulfate glycosaminoglycan (HS-GAG) chains. The aim of this study was to investigate BM HS-GAG expression in endometrial cancers. We investigated the expression of BM HS-GAG by immunohistochemistry in 109 endometrial cancers and analyzed correlations with various clinicopathological features. The HS-GAG expression index was significantly lower in cases of advanced stage, high-grade, deep myometrial invasion, positive peritoneal cytology, lymph vascular space invasion and lymph node metastasis. There was no association between HS-GAG expression status and patient outcome. Decreased HS-GAG expression of BM is associated with tumor progression, but is not be a useful prognostic factor in patients presenting with endometrial cancer.

KW - Basement membrane

KW - Endometrial cancer

KW - Heparan sulfate

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UR - http://www.scopus.com/inward/citedby.url?scp=23744468224&partnerID=8YFLogxK

M3 - Article

C2 - 16122188

AN - SCOPUS:23744468224

SN - 0392-2936

VL - 26

SP - 403

EP - 406

JO - European Journal of Gynaecological Oncology

JF - European Journal of Gynaecological Oncology

IS - 4

ER -

Loss of basement membrane heparan sulfate expression is associated with tumor progression in endometrial cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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