TY - JOUR
T1 - Longitudinal correspondence of epilepsy and scalp EEG fast (40–200 Hz) oscillations in pediatric patients with tuberous sclerosis complex
AU - Tsuchiya, Hiroki
AU - Endoh, Fumika
AU - Akiyama, Tomoyuki
AU - Matsuhashi, Masao
AU - Kobayashi, Katsuhiro
N1 - Funding Information:
We thank Dr. Nicol?s von Ellenrieder at the Montreal Neurological Institute, McGill University, for kindly providing us with the Matlab program for semi-automatic HFO/FO detection that was used in the present report. We also thank Professor Eiji Nanba at the Division of Functional Genomics, Research Centre for Bioscience and Technology, Tottori University, for providing us with the clinical genetic test result regarding patient #7. K. Kobayashi was supported by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT KAKENHI Grant Number 15H05874 [Non-linear Neuro-oscillology]), Research-Aids from Eisai Co. Ltd. and Otsuka Pharmaceutical Co. Ltd. and by Health and Labour Research Grants from the Ministry of Health, Labour and Welfare, Japan (H24-nanchitou-ippan-029, H26-nanchitou-ippan-051, H29-nanchitou-ippan-010, and 19GC1013). T. Akiyama was supported by Grants-in-Aid from the Japan Society for the Promotion of Science (JSPS KAKENHI Grant Number JP15K09622). M. Matsuhashi was supported by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT KAKENHI Grant Number 15H05875 [Non-linear Neuro-oscillology]). The Department of Epilepsy, Movement Disorders and Physiology, Kyoto University, is involved in an Industry?Academia Collaboration Course and supported by Eisai Co. Ltd. Nihon Kohden Corporation, Otsuka Pharmaceutical Co. Ltd. and UCB Japan Co. Ltd. The authors have no other conflicts of interest to disclose.
Funding Information:
K. Kobayashi was supported by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT KAKENHI Grant Number 15H05874 [Non-linear Neuro-oscillology]), Research-Aids from Eisai Co., Ltd. and Otsuka Pharmaceutical Co., Ltd., and by Health and Labour Research Grants from the Ministry of Health, Labour and Welfare, Japan (H24-nanchitou-ippan-029, H26-nanchitou-ippan-051, H29-nanchitou-ippan-010, and 19GC1013). T. Akiyama was supported by Grants-in-Aid from the Japan Society for the Promotion of Science (JSPS KAKENHI Grant Number JP15K09622 ).
Funding Information:
M. Matsuhashi was supported by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT KAKENHI Grant Number 15H05875 [Non-linear Neuro-oscillology]). The Department of Epilepsy, Movement Disorders and Physiology, Kyoto University, is involved in an Industry–Academia Collaboration Course and supported by Eisai Co., Ltd., Nihon Kohden Corporation, Otsuka Pharmaceutical Co., Ltd. and UCB Japan Co. Ltd.
Publisher Copyright:
© 2020 The Japanese Society of Child Neurology
PY - 2020/10
Y1 - 2020/10
N2 - Introduction: Epilepsy associated with tuberous sclerosis complex (TSC) has very complex clinical characteristics. Scalp electroencephalogram (EEG) fast (40–200 Hz) oscillations (FOs) were recently suggested to indicate epilepsy severity. Epileptic FOs may undergo age-dependent longitudinal change in individual patients, however, and the typical pattern of such change is not yet fully clarified. We therefore investigated the age-related correspondence between clinical courses and FOs in pediatric patients with TSC-associated epilepsy. Subjects and methods: FOs were semi-automatically detected from scalp sleep EEG data recorded from 23 children (15 boys, 8 girls; initial data obtained at <10 years of age) with TSC-associated epilepsy. Results: The number of FOs per patient that were associated with spikes was significantly greater than that of FOs unassociated with spikes (median 145 and 5, respectively; p = 0.0001 by the Wilcoxon signed-rank test). In the eight patients who had West syndrome (WS) in infancy, FOs associated with spikes were abundant during the WS period prior to adrenocorticotropic hormone therapy, with significantly greater numbers of FOs compared to the post-WS period (median 242 and 0, respectively; p = 0.0078). As there was no such time-dependent difference regarding FOs unassociated with spikes, FOs associated with spikes were identified as epileptic. The detected FOs included both gamma and ripple oscillations with no consistent age-dependent shifts in dominant frequency. There were no apparent age-related changes in FO duration. Conclusions: Epileptic scalp FOs are confirmed to correspond to severity of epileptic encephalopathy, particularly in WS, even during the long-term evolutional courses of TSC-associated epilepsy.
AB - Introduction: Epilepsy associated with tuberous sclerosis complex (TSC) has very complex clinical characteristics. Scalp electroencephalogram (EEG) fast (40–200 Hz) oscillations (FOs) were recently suggested to indicate epilepsy severity. Epileptic FOs may undergo age-dependent longitudinal change in individual patients, however, and the typical pattern of such change is not yet fully clarified. We therefore investigated the age-related correspondence between clinical courses and FOs in pediatric patients with TSC-associated epilepsy. Subjects and methods: FOs were semi-automatically detected from scalp sleep EEG data recorded from 23 children (15 boys, 8 girls; initial data obtained at <10 years of age) with TSC-associated epilepsy. Results: The number of FOs per patient that were associated with spikes was significantly greater than that of FOs unassociated with spikes (median 145 and 5, respectively; p = 0.0001 by the Wilcoxon signed-rank test). In the eight patients who had West syndrome (WS) in infancy, FOs associated with spikes were abundant during the WS period prior to adrenocorticotropic hormone therapy, with significantly greater numbers of FOs compared to the post-WS period (median 242 and 0, respectively; p = 0.0078). As there was no such time-dependent difference regarding FOs unassociated with spikes, FOs associated with spikes were identified as epileptic. The detected FOs included both gamma and ripple oscillations with no consistent age-dependent shifts in dominant frequency. There were no apparent age-related changes in FO duration. Conclusions: Epileptic scalp FOs are confirmed to correspond to severity of epileptic encephalopathy, particularly in WS, even during the long-term evolutional courses of TSC-associated epilepsy.
KW - Fast oscillations
KW - High-frequency oscillations
KW - Scalp EEG
KW - Tuberous sclerosis complex
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U2 - 10.1016/j.braindev.2020.06.001
DO - 10.1016/j.braindev.2020.06.001
M3 - Article
C2 - 32631641
AN - SCOPUS:85087393806
VL - 42
SP - 663
EP - 674
JO - Brain and Development
JF - Brain and Development
SN - 0387-7604
IS - 9
ER -