Longitudinal association among endothelial function, arterial stiffness and subclinical organ damage in hypertension

Hirofumi Tomiyama, Tomoko Ishizu, Takahide Kohro, Chisa Matsumoto, Yukihito Higashi, Bonpei Takase, Toru Suzuki, Shinichiro Ueda, Tsutomu Yamazaki, Tomoo Furumoto, Kazuomi Kario, Teruo Inoue, Shinji Koba, Yasuhiko Takemoto, Takuzo Hano, Masataka Sata, Yutaka Ishibashi, Koichi Node, Koji Maemura, Yusuke OhyaTaiji Furukawa, Hiroshi Ito, Akira Yamashina

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objectives To examine the longitudinal mutual association between endothelial dysfunction and arterial stiffness, and also to determine which of the two variables was more closely associated with the progression of subclinical organ damage. Methods The brachial-ankle pulse wave velocity (baPWV), carotid intima-media thickness (CIMT), estimated glomerular filtration rate, microalbuminuria and flow-mediated vasodilatation of the brachial artery (FMD) were measured three times at 1.5-year intervals in 674 Japanese patients receiving antihypertensive treatment. Results The change of the baPWV during the study period was larger in the subjects with baseline FMD values in the lowest tertile as compared to those with baseline FMD values in the highest tertile. The change of the CIMT was smaller in the subjects with baseline baPWV values in the lowest tertile than in those with baseline baPWV values in the highest tertile. After the adjustment, the FMD value at the baseline was inversely associated with the baPWV at the end of the study period (beta = − 0.07, p = 0.01), although, the reverse association was not significant. The baPWV, but not the FMD value, at the baseline was associated with the CIMT (beta = 0.06, p = 0.04) measured at the end of the study period. Conclusions In hypertension, endothelial dysfunction was associated with the progression of arterial stiffness, although the reverse association was not confirmed. The increased arterial stiffness rather than endothelial dysfunction may be more closely associated with the progression of atherosclerotic vascular damage, and the endothelial dysfunction-arterial stiffness-atherosclerosis continuum may be important in hypertension.

Original languageEnglish
Pages (from-to)161-166
Number of pages6
JournalInternational Journal of Cardiology
Volume253
DOIs
Publication statusPublished - Feb 15 2018

Keywords

  • Arterial stiffness
  • Atherosclerosis
  • Endothelial function
  • Hypertension
  • Renal function

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Tomiyama, H., Ishizu, T., Kohro, T., Matsumoto, C., Higashi, Y., Takase, B., Suzuki, T., Ueda, S., Yamazaki, T., Furumoto, T., Kario, K., Inoue, T., Koba, S., Takemoto, Y., Hano, T., Sata, M., Ishibashi, Y., Node, K., Maemura, K., ... Yamashina, A. (2018). Longitudinal association among endothelial function, arterial stiffness and subclinical organ damage in hypertension. International Journal of Cardiology, 253, 161-166. https://doi.org/10.1016/j.ijcard.2017.11.022