Abstract
Background. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase and an independent predictor of overall mortality and cardiovascular outcome in haemodialysis (HD) patients. In the present study, we compared the effects of a vitamin E-coated polysulfone membrane (PSE) and a non-vitamin E-coated polysulfone membrane (PS) on oxidative stress markers such as ADMA. Methods. Thirty-one HD patients were enrolled to this investigation. They were allocated into two groups: In the PSE group (n= 16), PSE was used for 6 months, followed by PS for an additional 12 months; in the PS group (n= 15), PS was used for the entire observation period. Plasma ADMA, oxidized low density lipoprotein (Ox-LDL) and malondialdehyde LDL (MDA-LDL) levels were measured at baseline, 3, 6, 12 and 18 months. Plasma ADMA in peritoneal dialysis (PD) patients and in healthy individuals was also measured. Results. Predialysis concentrations of ADMA (0.72± 0.13nmol/ml) were significantly higher in the HD group than in both PD patients (0.63±0.10nmol/ml,P
| Original language | English |
|---|---|
| Pages (from-to) | 2775-2782 |
| Number of pages | 8 |
| Journal | Nephrology Dialysis Transplantation |
| Volume | 20 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 2005 |
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Keywords
- ADMA
- Haemodialysis
- Oxidative stress
- Polysulfone
- Vitamin E-coated
ASJC Scopus subject areas
- Nephrology
- Transplantation
Cite this
Long-term use of vitamin E-coated polysulfone membrane reduces oxidative stress markers in haemodialysis patients. / Morimoto, Hisanori; Nakao, Kazushi; Fukuoka, Kousuke; Sarai, Ai; Yano, Ai; Kihara, Takashi; Fukuda, Shinji; Wada, Jun; Makino, Hirofumi.
In: Nephrology Dialysis Transplantation, Vol. 20, No. 12, 12.2005, p. 2775-2782.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Long-term use of vitamin E-coated polysulfone membrane reduces oxidative stress markers in haemodialysis patients
AU - Morimoto, Hisanori
AU - Nakao, Kazushi
AU - Fukuoka, Kousuke
AU - Sarai, Ai
AU - Yano, Ai
AU - Kihara, Takashi
AU - Fukuda, Shinji
AU - Wada, Jun
AU - Makino, Hirofumi
PY - 2005/12
Y1 - 2005/12
N2 - Background. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase and an independent predictor of overall mortality and cardiovascular outcome in haemodialysis (HD) patients. In the present study, we compared the effects of a vitamin E-coated polysulfone membrane (PSE) and a non-vitamin E-coated polysulfone membrane (PS) on oxidative stress markers such as ADMA. Methods. Thirty-one HD patients were enrolled to this investigation. They were allocated into two groups: In the PSE group (n= 16), PSE was used for 6 months, followed by PS for an additional 12 months; in the PS group (n= 15), PS was used for the entire observation period. Plasma ADMA, oxidized low density lipoprotein (Ox-LDL) and malondialdehyde LDL (MDA-LDL) levels were measured at baseline, 3, 6, 12 and 18 months. Plasma ADMA in peritoneal dialysis (PD) patients and in healthy individuals was also measured. Results. Predialysis concentrations of ADMA (0.72± 0.13nmol/ml) were significantly higher in the HD group than in both PD patients (0.63±0.10nmol/ml,P
AB - Background. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase and an independent predictor of overall mortality and cardiovascular outcome in haemodialysis (HD) patients. In the present study, we compared the effects of a vitamin E-coated polysulfone membrane (PSE) and a non-vitamin E-coated polysulfone membrane (PS) on oxidative stress markers such as ADMA. Methods. Thirty-one HD patients were enrolled to this investigation. They were allocated into two groups: In the PSE group (n= 16), PSE was used for 6 months, followed by PS for an additional 12 months; in the PS group (n= 15), PS was used for the entire observation period. Plasma ADMA, oxidized low density lipoprotein (Ox-LDL) and malondialdehyde LDL (MDA-LDL) levels were measured at baseline, 3, 6, 12 and 18 months. Plasma ADMA in peritoneal dialysis (PD) patients and in healthy individuals was also measured. Results. Predialysis concentrations of ADMA (0.72± 0.13nmol/ml) were significantly higher in the HD group than in both PD patients (0.63±0.10nmol/ml,P
KW - ADMA
KW - Haemodialysis
KW - Oxidative stress
KW - Polysulfone
KW - Vitamin E-coated
UR - http://www.scopus.com/inward/record.url?scp=27944486739&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=27944486739&partnerID=8YFLogxK
U2 - 10.1093/ndt/gfi121
DO - 10.1093/ndt/gfi121
M3 - Article
C2 - 16221689
AN - SCOPUS:27944486739
VL - 20
SP - 2775
EP - 2782
JO - Nephrology Dialysis Transplantation
JF - Nephrology Dialysis Transplantation
SN - 0931-0509
IS - 12
ER -