Long-term treatment with hyperbaric air improves hy-perlipidemia of db/db mice

Kiyoshi Teshigawara; Toshio Hosaka; Miwa Yamaguchi; Eri Terada; Yuka Kisyuku; Keiko Fukunaga; Yohko Hirata; Bayasgalan Jambaldorj; Nagakatsu Harada; Tohru Sakai; Yutaka Nakaya

doi:10.2152/jmi.57.224

Long-term treatment with hyperbaric air improves hy-perlipidemia of db/db mice

Kiyoshi Teshigawara, Toshio Hosaka, Miwa Yamaguchi, Eri Terada, Yuka Kisyuku, Keiko Fukunaga, Yohko Hirata, Bayasgalan Jambaldorj, Nagakatsu Harada, Tohru Sakai, Yutaka Nakaya

Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Hyperbaric air (HBA) is used to improve healing of wounds including diabetic ulcer. The aim of this study was to clarify the effects of HBA exposure on lipid and glucose metabolism in db/db mice. HBA did not influence the weight of db/db mice. Serum levels of free fatty acid and triglyceride, but not glucose and insulin, were significantly decreased after 6 weeks of treatment with HBA. The mRNA expressions of CPT-1, PPARα and PGC-1α genes, which are related to lipid metabolism, were significantly up-regulated in the muscle and liver. Increases in TNFα and MCP1 mRNA, which impaired lipid metabolism, were also attenuated by HBA treatment. These results suggest that exposure of HBA could have beneficial effects on lipid metabolism in patients with type 2 diabetes mellitus.

Original language	English
Pages (from-to)	224-231
Number of pages	8
Journal	Journal of Medical Investigation
Volume	57
Issue number	3-4
DOIs	https://doi.org/10.2152/jmi.57.224
Publication status	Published - Aug 2010

Keywords

HBA
Hyperlipidemia
MCP1
TNFα

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2152/jmi.57.224

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title = "Long-term treatment with hyperbaric air improves hy-perlipidemia of db/db mice",

abstract = "Hyperbaric air (HBA) is used to improve healing of wounds including diabetic ulcer. The aim of this study was to clarify the effects of HBA exposure on lipid and glucose metabolism in db/db mice. HBA did not influence the weight of db/db mice. Serum levels of free fatty acid and triglyceride, but not glucose and insulin, were significantly decreased after 6 weeks of treatment with HBA. The mRNA expressions of CPT-1, PPARα and PGC-1α genes, which are related to lipid metabolism, were significantly up-regulated in the muscle and liver. Increases in TNFα and MCP1 mRNA, which impaired lipid metabolism, were also attenuated by HBA treatment. These results suggest that exposure of HBA could have beneficial effects on lipid metabolism in patients with type 2 diabetes mellitus.",

keywords = "HBA, Hyperlipidemia, MCP1, TNFα",

author = "Kiyoshi Teshigawara and Toshio Hosaka and Miwa Yamaguchi and Eri Terada and Yuka Kisyuku and Keiko Fukunaga and Yohko Hirata and Bayasgalan Jambaldorj and Nagakatsu Harada and Tohru Sakai and Yutaka Nakaya",

year = "2010",

month = aug,

doi = "10.2152/jmi.57.224",

language = "English",

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pages = "224--231",

journal = "Journal of Medical Investigation",

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T1 - Long-term treatment with hyperbaric air improves hy-perlipidemia of db/db mice

AU - Teshigawara, Kiyoshi

AU - Hosaka, Toshio

AU - Yamaguchi, Miwa

AU - Terada, Eri

AU - Kisyuku, Yuka

AU - Fukunaga, Keiko

AU - Hirata, Yohko

AU - Jambaldorj, Bayasgalan

AU - Harada, Nagakatsu

AU - Sakai, Tohru

AU - Nakaya, Yutaka

PY - 2010/8

Y1 - 2010/8

N2 - Hyperbaric air (HBA) is used to improve healing of wounds including diabetic ulcer. The aim of this study was to clarify the effects of HBA exposure on lipid and glucose metabolism in db/db mice. HBA did not influence the weight of db/db mice. Serum levels of free fatty acid and triglyceride, but not glucose and insulin, were significantly decreased after 6 weeks of treatment with HBA. The mRNA expressions of CPT-1, PPARα and PGC-1α genes, which are related to lipid metabolism, were significantly up-regulated in the muscle and liver. Increases in TNFα and MCP1 mRNA, which impaired lipid metabolism, were also attenuated by HBA treatment. These results suggest that exposure of HBA could have beneficial effects on lipid metabolism in patients with type 2 diabetes mellitus.

AB - Hyperbaric air (HBA) is used to improve healing of wounds including diabetic ulcer. The aim of this study was to clarify the effects of HBA exposure on lipid and glucose metabolism in db/db mice. HBA did not influence the weight of db/db mice. Serum levels of free fatty acid and triglyceride, but not glucose and insulin, were significantly decreased after 6 weeks of treatment with HBA. The mRNA expressions of CPT-1, PPARα and PGC-1α genes, which are related to lipid metabolism, were significantly up-regulated in the muscle and liver. Increases in TNFα and MCP1 mRNA, which impaired lipid metabolism, were also attenuated by HBA treatment. These results suggest that exposure of HBA could have beneficial effects on lipid metabolism in patients with type 2 diabetes mellitus.

KW - HBA

KW - Hyperlipidemia

KW - MCP1

KW - TNFα

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DO - 10.2152/jmi.57.224

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AN - SCOPUS:78649637960

SN - 1343-1420

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JO - Journal of Medical Investigation

JF - Journal of Medical Investigation

IS - 3-4

ER -

Long-term treatment with hyperbaric air improves hy-perlipidemia of db/db mice

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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