Long-term survival in a patient with small-cell lung cancer undergoing hemodialysis who received multiple courses of chemotherapy

Yosuke Togashi, Young Hak Kim, Katsuhiro Masago, Yuichi Sakamori, Chiyuki Okuda, Tadashi Mio, Michiaki Mishima

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

The prognosis of small-cell lung cancer remains poor and it is speculated that small-cell lung cancer patients with end-stage renal failure undergoing hemodialysis have a poorer prognosis. In this article, we present a Japanese woman with extensive small-cell lung cancer with end-stage renal failure undergoing hemodialysis who received multiple courses of chemotherapy. Although she achieved long-term survival of more than 2 years, the last-line chemotherapy, consisting of irinotecan, induced grade 4 febrile neutropenia and her performance status deteriorated even with a reduced dose according to the analysis of UDP-glucuronosyltransferase 1A1. We also conducted a pharmacokinetic analysis of irinotecan, the resulting values of which were much higher than in previous reports. Although further studies are needed, chemotherapy for small-cell lung cancer patients should not be withheld just because they are undergoing hemodialysis; however, chemotherapy should be performed more carefully because more severe toxicities can occur than expected.

Original languageEnglish
Article numberhyq244
Pages (from-to)582-585
Number of pages4
JournalJapanese journal of clinical oncology
Volume41
Issue number4
DOIs
Publication statusPublished - Apr 2011
Externally publishedYes

Keywords

  • Hemodialysis
  • Irinotecan
  • Multiple courses chemotherapy
  • Pharmacokinetics
  • Small-cell lung cancer

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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