Long-term survival following percutaneous radiofrequency ablation of colorectal lung metastases

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Abstract

Purpose: To retrospectively evaluate long-term survival outcomes of radiofrequency (RF) ablation of colorectal lung metastases and evaluate factors associated with improved survival. Materials and Methods: Eighty-four patients (46 male and 38 female; median age, 65 y) with 172 colorectal lung metastases (median size, 1.2 cm) underwent 113 RF ablation sessions. Thirteen patients had viable extrapulmonary recurrences at the time of RF ablation. The primary endpoint was patient survival. Prognostic factors associated with survival were determined by univariate and multivariate analyses. Secondary endpoints were local tumor progression and adverse events (per National Cancer Institute Common Terminology Criteria for Adverse Events, version 4.0). Results: During follow-up (median duration, 37.5 mo), 36 patients (42.9%) died. The estimated overall survival (OS) rates were 95.2%, 65.0%, and 51.6% at 1, 3, and 5 years, respectively (median OS time, 67.0 mo). Multivariate analysis revealed that a carcinoembryonic antigen (CEA) level of at least 5 ng/mL before RF ablation (P = .03) and the presence of viable extrapulmonary recurrences at the time of RF ablation (P = .001) were independent negative prognostic factors. The local tumor progression rate was 14.0% (24 of 172 tumors). Grade 3 adverse events were observed after two sessions (1.8%), and grade 4/5 adverse events were not observed. Conclusions: RF ablation of colorectal lung metastases provided favorable long-term survival with a low incidence of severe adverse events. Independent prognostic factors were a high CEA level before RF ablation and the presence of viable extrapulmonary recurrences at the time of RF ablation.& SIR, 2015.

Original languageEnglish
Pages (from-to)303-310
Number of pages8
JournalJournal of Vascular and Interventional Radiology
Volume26
Issue number3
DOIs
Publication statusPublished - 2015

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Neoplasm Metastasis
Lung
Survival
Carcinoembryonic Antigen
Recurrence
Multivariate Analysis
Neoplasms
National Cancer Institute (U.S.)
Terminology
Survival Rate
Incidence

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

@article{f937bc703c314e278e61b798ad7ca77e,
title = "Long-term survival following percutaneous radiofrequency ablation of colorectal lung metastases",
abstract = "Purpose: To retrospectively evaluate long-term survival outcomes of radiofrequency (RF) ablation of colorectal lung metastases and evaluate factors associated with improved survival. Materials and Methods: Eighty-four patients (46 male and 38 female; median age, 65 y) with 172 colorectal lung metastases (median size, 1.2 cm) underwent 113 RF ablation sessions. Thirteen patients had viable extrapulmonary recurrences at the time of RF ablation. The primary endpoint was patient survival. Prognostic factors associated with survival were determined by univariate and multivariate analyses. Secondary endpoints were local tumor progression and adverse events (per National Cancer Institute Common Terminology Criteria for Adverse Events, version 4.0). Results: During follow-up (median duration, 37.5 mo), 36 patients (42.9{\%}) died. The estimated overall survival (OS) rates were 95.2{\%}, 65.0{\%}, and 51.6{\%} at 1, 3, and 5 years, respectively (median OS time, 67.0 mo). Multivariate analysis revealed that a carcinoembryonic antigen (CEA) level of at least 5 ng/mL before RF ablation (P = .03) and the presence of viable extrapulmonary recurrences at the time of RF ablation (P = .001) were independent negative prognostic factors. The local tumor progression rate was 14.0{\%} (24 of 172 tumors). Grade 3 adverse events were observed after two sessions (1.8{\%}), and grade 4/5 adverse events were not observed. Conclusions: RF ablation of colorectal lung metastases provided favorable long-term survival with a low incidence of severe adverse events. Independent prognostic factors were a high CEA level before RF ablation and the presence of viable extrapulmonary recurrences at the time of RF ablation.& SIR, 2015.",
author = "Yusuke Matsui and Takao Hiraki and Hideo Gobara and Toshihiro Iguchi and Hiroyasu Fujiwara and Takeshi Nagasaka and Shinichi Toyooka and Susumu Kanazawa",
year = "2015",
doi = "10.1016/j.jvir.2014.11.013",
language = "English",
volume = "26",
pages = "303--310",
journal = "Journal of Vascular and Interventional Radiology",
issn = "1051-0443",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Long-term survival following percutaneous radiofrequency ablation of colorectal lung metastases

AU - Matsui, Yusuke

AU - Hiraki, Takao

AU - Gobara, Hideo

AU - Iguchi, Toshihiro

AU - Fujiwara, Hiroyasu

AU - Nagasaka, Takeshi

AU - Toyooka, Shinichi

AU - Kanazawa, Susumu

PY - 2015

Y1 - 2015

N2 - Purpose: To retrospectively evaluate long-term survival outcomes of radiofrequency (RF) ablation of colorectal lung metastases and evaluate factors associated with improved survival. Materials and Methods: Eighty-four patients (46 male and 38 female; median age, 65 y) with 172 colorectal lung metastases (median size, 1.2 cm) underwent 113 RF ablation sessions. Thirteen patients had viable extrapulmonary recurrences at the time of RF ablation. The primary endpoint was patient survival. Prognostic factors associated with survival were determined by univariate and multivariate analyses. Secondary endpoints were local tumor progression and adverse events (per National Cancer Institute Common Terminology Criteria for Adverse Events, version 4.0). Results: During follow-up (median duration, 37.5 mo), 36 patients (42.9%) died. The estimated overall survival (OS) rates were 95.2%, 65.0%, and 51.6% at 1, 3, and 5 years, respectively (median OS time, 67.0 mo). Multivariate analysis revealed that a carcinoembryonic antigen (CEA) level of at least 5 ng/mL before RF ablation (P = .03) and the presence of viable extrapulmonary recurrences at the time of RF ablation (P = .001) were independent negative prognostic factors. The local tumor progression rate was 14.0% (24 of 172 tumors). Grade 3 adverse events were observed after two sessions (1.8%), and grade 4/5 adverse events were not observed. Conclusions: RF ablation of colorectal lung metastases provided favorable long-term survival with a low incidence of severe adverse events. Independent prognostic factors were a high CEA level before RF ablation and the presence of viable extrapulmonary recurrences at the time of RF ablation.& SIR, 2015.

AB - Purpose: To retrospectively evaluate long-term survival outcomes of radiofrequency (RF) ablation of colorectal lung metastases and evaluate factors associated with improved survival. Materials and Methods: Eighty-four patients (46 male and 38 female; median age, 65 y) with 172 colorectal lung metastases (median size, 1.2 cm) underwent 113 RF ablation sessions. Thirteen patients had viable extrapulmonary recurrences at the time of RF ablation. The primary endpoint was patient survival. Prognostic factors associated with survival were determined by univariate and multivariate analyses. Secondary endpoints were local tumor progression and adverse events (per National Cancer Institute Common Terminology Criteria for Adverse Events, version 4.0). Results: During follow-up (median duration, 37.5 mo), 36 patients (42.9%) died. The estimated overall survival (OS) rates were 95.2%, 65.0%, and 51.6% at 1, 3, and 5 years, respectively (median OS time, 67.0 mo). Multivariate analysis revealed that a carcinoembryonic antigen (CEA) level of at least 5 ng/mL before RF ablation (P = .03) and the presence of viable extrapulmonary recurrences at the time of RF ablation (P = .001) were independent negative prognostic factors. The local tumor progression rate was 14.0% (24 of 172 tumors). Grade 3 adverse events were observed after two sessions (1.8%), and grade 4/5 adverse events were not observed. Conclusions: RF ablation of colorectal lung metastases provided favorable long-term survival with a low incidence of severe adverse events. Independent prognostic factors were a high CEA level before RF ablation and the presence of viable extrapulmonary recurrences at the time of RF ablation.& SIR, 2015.

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U2 - 10.1016/j.jvir.2014.11.013

DO - 10.1016/j.jvir.2014.11.013

M3 - Article

VL - 26

SP - 303

EP - 310

JO - Journal of Vascular and Interventional Radiology

JF - Journal of Vascular and Interventional Radiology

SN - 1051-0443

IS - 3

ER -