Long-term remission of hepatitis-associated aplastic anemia possibly due to immunosuppressive therapy after liver transplantation

Kiichiro Kanamitsu, Kousuke Chayama, Kana Washio, Ryuichi Yoshida, Yuzo Umeda, Takahito Yagi, Akira Shimada

Research output: Contribution to journalArticle

Abstract

Hepatitis-associated aplastic anemia (HAAA) is an acquired bone marrow failure syndrome that develops after seronegative fulminant hepatitis. Abnormal cytotoxic T-cell activation with cytokine release is a possible pathophysiology. We present the case of a 16-month-old Japanese male who developed HAAA following living- donor liver transplantation for fulminant hepatitis. His aplastic anemia was successfully treated with immunosuppressive therapy. He had been administered tacrolimus for prophylaxis against hepatic allograft rejection. Ten years after the HAAA onset, the patient's bone marrow was found to be slightly hypoplastic. Tacrolimus may be effective in controlling abnormal immune reactions that can cause recurrent impaired hematopoiesis.

Original languageEnglish
Pages (from-to)515-518
Number of pages4
JournalActa Medica Okayama
Volume72
Issue number5
Publication statusPublished - Jan 1 2018

Fingerprint

Aplastic Anemia
Tacrolimus
Immunosuppressive Agents
Liver
Liver Transplantation
Hepatitis
Bone
Antigen-antibody reactions
T-cells
Allografts
Chemical activation
Cytokines
Therapeutics
Living Donors
Hematopoiesis
Bone Marrow
T-Lymphocytes

Keywords

  • Abnormal immune reaction
  • Hepatitis-associated aplastic anemia
  • Immunosuppressive therapy
  • Impaired hematopoiesis
  • Liver transplantation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

@article{8b654a40a5274c8892da0b0747d18793,
title = "Long-term remission of hepatitis-associated aplastic anemia possibly due to immunosuppressive therapy after liver transplantation",
abstract = "Hepatitis-associated aplastic anemia (HAAA) is an acquired bone marrow failure syndrome that develops after seronegative fulminant hepatitis. Abnormal cytotoxic T-cell activation with cytokine release is a possible pathophysiology. We present the case of a 16-month-old Japanese male who developed HAAA following living- donor liver transplantation for fulminant hepatitis. His aplastic anemia was successfully treated with immunosuppressive therapy. He had been administered tacrolimus for prophylaxis against hepatic allograft rejection. Ten years after the HAAA onset, the patient's bone marrow was found to be slightly hypoplastic. Tacrolimus may be effective in controlling abnormal immune reactions that can cause recurrent impaired hematopoiesis.",
keywords = "Abnormal immune reaction, Hepatitis-associated aplastic anemia, Immunosuppressive therapy, Impaired hematopoiesis, Liver transplantation",
author = "Kiichiro Kanamitsu and Kousuke Chayama and Kana Washio and Ryuichi Yoshida and Yuzo Umeda and Takahito Yagi and Akira Shimada",
year = "2018",
month = "1",
day = "1",
language = "English",
volume = "72",
pages = "515--518",
journal = "Acta Medica Okayama",
issn = "0386-300X",
publisher = "Okayama University",
number = "5",

}

TY - JOUR

T1 - Long-term remission of hepatitis-associated aplastic anemia possibly due to immunosuppressive therapy after liver transplantation

AU - Kanamitsu, Kiichiro

AU - Chayama, Kousuke

AU - Washio, Kana

AU - Yoshida, Ryuichi

AU - Umeda, Yuzo

AU - Yagi, Takahito

AU - Shimada, Akira

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Hepatitis-associated aplastic anemia (HAAA) is an acquired bone marrow failure syndrome that develops after seronegative fulminant hepatitis. Abnormal cytotoxic T-cell activation with cytokine release is a possible pathophysiology. We present the case of a 16-month-old Japanese male who developed HAAA following living- donor liver transplantation for fulminant hepatitis. His aplastic anemia was successfully treated with immunosuppressive therapy. He had been administered tacrolimus for prophylaxis against hepatic allograft rejection. Ten years after the HAAA onset, the patient's bone marrow was found to be slightly hypoplastic. Tacrolimus may be effective in controlling abnormal immune reactions that can cause recurrent impaired hematopoiesis.

AB - Hepatitis-associated aplastic anemia (HAAA) is an acquired bone marrow failure syndrome that develops after seronegative fulminant hepatitis. Abnormal cytotoxic T-cell activation with cytokine release is a possible pathophysiology. We present the case of a 16-month-old Japanese male who developed HAAA following living- donor liver transplantation for fulminant hepatitis. His aplastic anemia was successfully treated with immunosuppressive therapy. He had been administered tacrolimus for prophylaxis against hepatic allograft rejection. Ten years after the HAAA onset, the patient's bone marrow was found to be slightly hypoplastic. Tacrolimus may be effective in controlling abnormal immune reactions that can cause recurrent impaired hematopoiesis.

KW - Abnormal immune reaction

KW - Hepatitis-associated aplastic anemia

KW - Immunosuppressive therapy

KW - Impaired hematopoiesis

KW - Liver transplantation

UR - http://www.scopus.com/inward/record.url?scp=85055616187&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85055616187&partnerID=8YFLogxK

M3 - Article

C2 - 30369609

AN - SCOPUS:85055616187

VL - 72

SP - 515

EP - 518

JO - Acta Medica Okayama

JF - Acta Medica Okayama

SN - 0386-300X

IS - 5

ER -