Long-term prognosis of patients with J-wave syndrome

Tsukasa Kamakura, Tetsuji Shinohara, Kenji Yodogawa, Nobuyuki Murakoshi, Hiroshi Morita, Naohiko Takahashi, Yasuya Inden, Wataru Shimizu, Akihiko Nogami, Minoru Horie, Takeshi Aiba, Kengo Kusano

Research output: Contribution to journalArticle

Abstract

Objective: Limited data are currently available regarding the long-term prognosis of patients with J-wave syndrome (JWS). The aim of this study was to investigate the long-term prognosis of patients with JWS and identify predictors of the recurrence of ventricular fibrillation (VF). Methods: This was a multicentre retrospective study (seven Japanese hospitals) involving 134 patients with JWS (Brugada syndrome (BrS): 85; early repolarisation syndrome (ERS): 49) treated with an implantable cardioverter defibrillator. All patients had a history of VF. All patients with ERS underwent drug provocation testing with standard and high intercostal ECG recordings to rule out BrS. The impact of global J waves (type 1 ECG or anterior J waves and inferolateral J waves in two or more leads) on the prognosis was evaluated. Results: During the 91±66 months of the follow-up period, 52 (39%) patients (BrS: 37; ERS: 15) experienced recurrence of VF. Patients with BrS and ERS with global J waves showed a significantly higher incidence of VF recurrence than those without (BrS: log-rank, p=0.014; ERS: log-rank, p=0.0009). The presence of global J waves was a predictor of VF recurrence in patients with JWS (HR: 2.16, 95% CI 1.21 to 3.91, p=0.0095), while previously reported high-risk electrocardiographic parameters (high-amplitude J waves ≥0.2 mV and J waves associated with a horizontal or descending ST segment) were not predictive of VF recurrence. Conclusions: This multicentre long-term study showed that the presence of global J waves was associated with a higher incidence of VF recurrence in patients with JWS.

Original languageEnglish
JournalHeart
DOIs
Publication statusAccepted/In press - Jan 1 2019

Fingerprint

Ventricular Fibrillation
Brugada Syndrome
Recurrence
Electrocardiography
Implantable Defibrillators
Incidence
Multicenter Studies
Retrospective Studies
Pharmaceutical Preparations

Keywords

  • brugada syndrome
  • early repolarisation syndrome
  • j wave
  • j-wave syndrome
  • ventricular fibrillation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Kamakura, T., Shinohara, T., Yodogawa, K., Murakoshi, N., Morita, H., Takahashi, N., ... Kusano, K. (Accepted/In press). Long-term prognosis of patients with J-wave syndrome. Heart. https://doi.org/10.1136/heartjnl-2019-315007

Long-term prognosis of patients with J-wave syndrome. / Kamakura, Tsukasa; Shinohara, Tetsuji; Yodogawa, Kenji; Murakoshi, Nobuyuki; Morita, Hiroshi; Takahashi, Naohiko; Inden, Yasuya; Shimizu, Wataru; Nogami, Akihiko; Horie, Minoru; Aiba, Takeshi; Kusano, Kengo.

In: Heart, 01.01.2019.

Research output: Contribution to journalArticle

Kamakura, T, Shinohara, T, Yodogawa, K, Murakoshi, N, Morita, H, Takahashi, N, Inden, Y, Shimizu, W, Nogami, A, Horie, M, Aiba, T & Kusano, K 2019, 'Long-term prognosis of patients with J-wave syndrome', Heart. https://doi.org/10.1136/heartjnl-2019-315007
Kamakura T, Shinohara T, Yodogawa K, Murakoshi N, Morita H, Takahashi N et al. Long-term prognosis of patients with J-wave syndrome. Heart. 2019 Jan 1. https://doi.org/10.1136/heartjnl-2019-315007
Kamakura, Tsukasa ; Shinohara, Tetsuji ; Yodogawa, Kenji ; Murakoshi, Nobuyuki ; Morita, Hiroshi ; Takahashi, Naohiko ; Inden, Yasuya ; Shimizu, Wataru ; Nogami, Akihiko ; Horie, Minoru ; Aiba, Takeshi ; Kusano, Kengo. / Long-term prognosis of patients with J-wave syndrome. In: Heart. 2019.
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abstract = "Objective: Limited data are currently available regarding the long-term prognosis of patients with J-wave syndrome (JWS). The aim of this study was to investigate the long-term prognosis of patients with JWS and identify predictors of the recurrence of ventricular fibrillation (VF). Methods: This was a multicentre retrospective study (seven Japanese hospitals) involving 134 patients with JWS (Brugada syndrome (BrS): 85; early repolarisation syndrome (ERS): 49) treated with an implantable cardioverter defibrillator. All patients had a history of VF. All patients with ERS underwent drug provocation testing with standard and high intercostal ECG recordings to rule out BrS. The impact of global J waves (type 1 ECG or anterior J waves and inferolateral J waves in two or more leads) on the prognosis was evaluated. Results: During the 91±66 months of the follow-up period, 52 (39{\%}) patients (BrS: 37; ERS: 15) experienced recurrence of VF. Patients with BrS and ERS with global J waves showed a significantly higher incidence of VF recurrence than those without (BrS: log-rank, p=0.014; ERS: log-rank, p=0.0009). The presence of global J waves was a predictor of VF recurrence in patients with JWS (HR: 2.16, 95{\%} CI 1.21 to 3.91, p=0.0095), while previously reported high-risk electrocardiographic parameters (high-amplitude J waves ≥0.2 mV and J waves associated with a horizontal or descending ST segment) were not predictive of VF recurrence. Conclusions: This multicentre long-term study showed that the presence of global J waves was associated with a higher incidence of VF recurrence in patients with JWS.",
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author = "Tsukasa Kamakura and Tetsuji Shinohara and Kenji Yodogawa and Nobuyuki Murakoshi and Hiroshi Morita and Naohiko Takahashi and Yasuya Inden and Wataru Shimizu and Akihiko Nogami and Minoru Horie and Takeshi Aiba and Kengo Kusano",
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T1 - Long-term prognosis of patients with J-wave syndrome

AU - Kamakura, Tsukasa

AU - Shinohara, Tetsuji

AU - Yodogawa, Kenji

AU - Murakoshi, Nobuyuki

AU - Morita, Hiroshi

AU - Takahashi, Naohiko

AU - Inden, Yasuya

AU - Shimizu, Wataru

AU - Nogami, Akihiko

AU - Horie, Minoru

AU - Aiba, Takeshi

AU - Kusano, Kengo

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Objective: Limited data are currently available regarding the long-term prognosis of patients with J-wave syndrome (JWS). The aim of this study was to investigate the long-term prognosis of patients with JWS and identify predictors of the recurrence of ventricular fibrillation (VF). Methods: This was a multicentre retrospective study (seven Japanese hospitals) involving 134 patients with JWS (Brugada syndrome (BrS): 85; early repolarisation syndrome (ERS): 49) treated with an implantable cardioverter defibrillator. All patients had a history of VF. All patients with ERS underwent drug provocation testing with standard and high intercostal ECG recordings to rule out BrS. The impact of global J waves (type 1 ECG or anterior J waves and inferolateral J waves in two or more leads) on the prognosis was evaluated. Results: During the 91±66 months of the follow-up period, 52 (39%) patients (BrS: 37; ERS: 15) experienced recurrence of VF. Patients with BrS and ERS with global J waves showed a significantly higher incidence of VF recurrence than those without (BrS: log-rank, p=0.014; ERS: log-rank, p=0.0009). The presence of global J waves was a predictor of VF recurrence in patients with JWS (HR: 2.16, 95% CI 1.21 to 3.91, p=0.0095), while previously reported high-risk electrocardiographic parameters (high-amplitude J waves ≥0.2 mV and J waves associated with a horizontal or descending ST segment) were not predictive of VF recurrence. Conclusions: This multicentre long-term study showed that the presence of global J waves was associated with a higher incidence of VF recurrence in patients with JWS.

AB - Objective: Limited data are currently available regarding the long-term prognosis of patients with J-wave syndrome (JWS). The aim of this study was to investigate the long-term prognosis of patients with JWS and identify predictors of the recurrence of ventricular fibrillation (VF). Methods: This was a multicentre retrospective study (seven Japanese hospitals) involving 134 patients with JWS (Brugada syndrome (BrS): 85; early repolarisation syndrome (ERS): 49) treated with an implantable cardioverter defibrillator. All patients had a history of VF. All patients with ERS underwent drug provocation testing with standard and high intercostal ECG recordings to rule out BrS. The impact of global J waves (type 1 ECG or anterior J waves and inferolateral J waves in two or more leads) on the prognosis was evaluated. Results: During the 91±66 months of the follow-up period, 52 (39%) patients (BrS: 37; ERS: 15) experienced recurrence of VF. Patients with BrS and ERS with global J waves showed a significantly higher incidence of VF recurrence than those without (BrS: log-rank, p=0.014; ERS: log-rank, p=0.0009). The presence of global J waves was a predictor of VF recurrence in patients with JWS (HR: 2.16, 95% CI 1.21 to 3.91, p=0.0095), while previously reported high-risk electrocardiographic parameters (high-amplitude J waves ≥0.2 mV and J waves associated with a horizontal or descending ST segment) were not predictive of VF recurrence. Conclusions: This multicentre long-term study showed that the presence of global J waves was associated with a higher incidence of VF recurrence in patients with JWS.

KW - brugada syndrome

KW - early repolarisation syndrome

KW - j wave

KW - j-wave syndrome

KW - ventricular fibrillation

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