Long-term parvovirus B19 infections with genetic drift after cord blood transplantation complicated by persistent CD4+ lymphocytopenia

Michio Suzuki, Yoshinori Ito, Akira Shimada, Mika Saito, Hideki Muramatsu, Asahito Hama, Yoshiyuki Takahashi, Hirokazu Kimura, Seiji Kojima

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A 5-month-old girl was diagnosed with Langerhans cell histiocytosis and received unrelated umbilical cord blood transplantation at the age of 14 months. After cord blood transplantation, CD4 lymphocytopenia from unknown causes was observed, and persistent infections with human parvovirus B19 (B19) occurred. We performed repeated longitudinal genetic analysis for B19, which revealed 6 nucleotide mutations in B19 nonstructural protein regions in the patient. The resulting changes of the nonstructural 1 structure may have altered antigenicity of the virus and could play a role in the pathogenesis of persistent infection under immunocompromised conditions.

Original languageEnglish
Pages (from-to)e65-e68
JournalJournal of Pediatric Hematology/Oncology
Volume36
Issue number1
DOIs
Publication statusPublished - Jan 1 2014

Keywords

  • Cord blood transplantation
  • Genetic drift
  • Lymphocytopenia
  • Parvovirus B19

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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