Long-Term Outcome in Patients with a Solitary Peutz-Jeghers Polyp

Masaya Iwamuro, Yuki Aoyama, Seiyuu Suzuki, Sayo Kobayashi, Tatsuya Toyokawa, Yuki Moritou, Shinichiro Hori, Kazuhiro Matsueda, Masao Yoshioka, Takehiro Tanaka, Hiroyuki Okada

Research output: Contribution to journalArticle

Abstract

Clinical characteristics and prognosis of patients with a solitary Peutz-Jeghers polyp (PJP) have not been fully investigated. Methods. Solitary PJP was diagnosed when a single hamartomatous lesion was identified in the gastrointestinal tract of patients without mucocutaneous pigmentation or a family history of Peutz-Jeghers syndrome. We retrospectively reviewed 51 patients (32 men and 19 women) with a solitary PJP and analyzed the sex, age at diagnosis, endoscopic features, and outcomes in this patient group. The STK11/LKB1 germline mutation was not investigated in any of the patients. Results. The mean age of the 51 patients was 66.1 years. The polyp was found in the duodenum (N=10), jejunum (N=2), cecum (N=2), transverse colon (N=5), sigmoid colon (N=21), or rectum (N=11). Most of the polyps presented as a pedunculated lesion (N=40), followed by semipedunculated (N=9) and sessile (N=2) morphologies. The mean size of a solitary PJP was 15.6 mm (range: 5 to 33 mm). During a mean endoscopic follow-up period of 4.5 years (range: 0.1 to 16.1 years), no recurrence was identified. Eighteen of the enrolled patients had a history of cancer or concomitant cancer. Five patients died due to non-gastrointestinal-related causes. No additional cancer or death directly related to solitary PJP was observed. Conclusions. Solitary PJPs did not recur in this study. Although examination of the entire gastrointestinal tract using esophagogastroduodenoscopy, enteroscopy, and colonoscopy is desirable to exclude Peutz-Jeghers syndrome, follow-up endoscopy after endoscopic polyp resection may be unnecessary, once the diagnosis of a solitary PJP is made.

Original languageEnglish
Article number8159072
JournalGastroenterology Research and Practice
Volume2019
DOIs
Publication statusPublished - Jan 1 2019

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Polyps
Peutz-Jeghers Syndrome
Gastrointestinal Tract
Digestive System Endoscopy
Neoplasms
Transverse Colon
Cecum
Germ-Line Mutation
Pigmentation
Sigmoid Colon
Jejunum
Colonoscopy
Duodenum
Rectum
Endoscopy
Recurrence

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Long-Term Outcome in Patients with a Solitary Peutz-Jeghers Polyp. / Iwamuro, Masaya; Aoyama, Yuki; Suzuki, Seiyuu; Kobayashi, Sayo; Toyokawa, Tatsuya; Moritou, Yuki; Hori, Shinichiro; Matsueda, Kazuhiro; Yoshioka, Masao; Tanaka, Takehiro; Okada, Hiroyuki.

In: Gastroenterology Research and Practice, Vol. 2019, 8159072, 01.01.2019.

Research output: Contribution to journalArticle

Iwamuro, M, Aoyama, Y, Suzuki, S, Kobayashi, S, Toyokawa, T, Moritou, Y, Hori, S, Matsueda, K, Yoshioka, M, Tanaka, T & Okada, H 2019, 'Long-Term Outcome in Patients with a Solitary Peutz-Jeghers Polyp', Gastroenterology Research and Practice, vol. 2019, 8159072. https://doi.org/10.1155/2019/8159072
Iwamuro, Masaya ; Aoyama, Yuki ; Suzuki, Seiyuu ; Kobayashi, Sayo ; Toyokawa, Tatsuya ; Moritou, Yuki ; Hori, Shinichiro ; Matsueda, Kazuhiro ; Yoshioka, Masao ; Tanaka, Takehiro ; Okada, Hiroyuki. / Long-Term Outcome in Patients with a Solitary Peutz-Jeghers Polyp. In: Gastroenterology Research and Practice. 2019 ; Vol. 2019.
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AU - Suzuki, Seiyuu

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AU - Toyokawa, Tatsuya

AU - Moritou, Yuki

AU - Hori, Shinichiro

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AU - Tanaka, Takehiro

AU - Okada, Hiroyuki

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N2 - Clinical characteristics and prognosis of patients with a solitary Peutz-Jeghers polyp (PJP) have not been fully investigated. Methods. Solitary PJP was diagnosed when a single hamartomatous lesion was identified in the gastrointestinal tract of patients without mucocutaneous pigmentation or a family history of Peutz-Jeghers syndrome. We retrospectively reviewed 51 patients (32 men and 19 women) with a solitary PJP and analyzed the sex, age at diagnosis, endoscopic features, and outcomes in this patient group. The STK11/LKB1 germline mutation was not investigated in any of the patients. Results. The mean age of the 51 patients was 66.1 years. The polyp was found in the duodenum (N=10), jejunum (N=2), cecum (N=2), transverse colon (N=5), sigmoid colon (N=21), or rectum (N=11). Most of the polyps presented as a pedunculated lesion (N=40), followed by semipedunculated (N=9) and sessile (N=2) morphologies. The mean size of a solitary PJP was 15.6 mm (range: 5 to 33 mm). During a mean endoscopic follow-up period of 4.5 years (range: 0.1 to 16.1 years), no recurrence was identified. Eighteen of the enrolled patients had a history of cancer or concomitant cancer. Five patients died due to non-gastrointestinal-related causes. No additional cancer or death directly related to solitary PJP was observed. Conclusions. Solitary PJPs did not recur in this study. Although examination of the entire gastrointestinal tract using esophagogastroduodenoscopy, enteroscopy, and colonoscopy is desirable to exclude Peutz-Jeghers syndrome, follow-up endoscopy after endoscopic polyp resection may be unnecessary, once the diagnosis of a solitary PJP is made.

AB - Clinical characteristics and prognosis of patients with a solitary Peutz-Jeghers polyp (PJP) have not been fully investigated. Methods. Solitary PJP was diagnosed when a single hamartomatous lesion was identified in the gastrointestinal tract of patients without mucocutaneous pigmentation or a family history of Peutz-Jeghers syndrome. We retrospectively reviewed 51 patients (32 men and 19 women) with a solitary PJP and analyzed the sex, age at diagnosis, endoscopic features, and outcomes in this patient group. The STK11/LKB1 germline mutation was not investigated in any of the patients. Results. The mean age of the 51 patients was 66.1 years. The polyp was found in the duodenum (N=10), jejunum (N=2), cecum (N=2), transverse colon (N=5), sigmoid colon (N=21), or rectum (N=11). Most of the polyps presented as a pedunculated lesion (N=40), followed by semipedunculated (N=9) and sessile (N=2) morphologies. The mean size of a solitary PJP was 15.6 mm (range: 5 to 33 mm). During a mean endoscopic follow-up period of 4.5 years (range: 0.1 to 16.1 years), no recurrence was identified. Eighteen of the enrolled patients had a history of cancer or concomitant cancer. Five patients died due to non-gastrointestinal-related causes. No additional cancer or death directly related to solitary PJP was observed. Conclusions. Solitary PJPs did not recur in this study. Although examination of the entire gastrointestinal tract using esophagogastroduodenoscopy, enteroscopy, and colonoscopy is desirable to exclude Peutz-Jeghers syndrome, follow-up endoscopy after endoscopic polyp resection may be unnecessary, once the diagnosis of a solitary PJP is made.

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