Long-Term Efficacy of Galantamine in Alzheimer's Disease: The Okayama Galantamine Study (OGS)

Yumiko Nakano, Kosuke Matsuzono, Toru Yamashita, Yasuyuki Ohta, Nozomi Hishikawa, Kota Sato, Kentaro Deguchi, Koji Abe

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Background: Alzheimer's disease (AD) is one of the most significant diseases affecting an increasingly aging society. Objective: To determine the long-term efficacy of galantamine treatment in a Japanese population. Methods:We performed "Okayama Galantamine Study (OGS)" to retrospectively analyze the clinical effects of galantamine in 279 AD patients using 7 batteries for assessing dementia at baseline, 3, 6, 12, and 24 months.We further analyzed the effects of galantamine based on gender and the severity of their baseline cognitive, affective, and activity of daily living (ADL) functions. Results: In all 279ADpatients (80.6±7.2 years old,MMSE20.0±4.5), cognitive functions were well preserved until 12 months and even frontal assessment battery improved after 12 months although Hasegawa dementia scale-revised finally worsened at 24 months (p > 0.05) with galantamine treatment. Affective and ADL functions were also well maintained after galantamine treatment with significant improvement of Geriatric Depression Scale scores at 3 months (p > 0.05). Subanalyses showed the better response to galantamine for male and lower baseline function subgroups. Conclusions: Our present study (OGS) revealed a long-term efficacy of galantamine in very elderly AD patients, and suggested a better efficacy for male and baseline lower cognitive, affective, and ADL functions.

Original languageEnglish
Pages (from-to)609-617
Number of pages9
JournalJournal of Alzheimer's Disease
Volume47
Issue number3
DOIs
Publication statusPublished - Aug 3 2015

Keywords

  • Activity of daily living
  • Alzheimer's disease
  • affective function
  • cognitive function
  • dementia
  • galantamine

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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