Long-term effect of external beam radiotherapy of optic disc hemangioma in a patient with von hippel-lindau disease

Toshihiko Matsuo, Kengo Himei, Kouichi Ichimura, Hiroyuki Yanai, Soichiro Nose, Tetsushige Mimura, Yasuyuki Miyoshi, Tomoyasu Tsushima

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

An 18-year-old woman with a 2-year history of hypertension and headache was diagnosed with nora-drenalin-secreting bilateral adrenal pheochromocytomas with paragangliomas in the background of von Hippel-Lindau disease with family histories and a missense mutation, 712C to T (Argl67Trp) in the VHL gene. She had optic disc hemangioma in the left eye which gradually enlarged and caused serous retinal detachment on the macula in one year. Low-dose external beam radiation (20 Gy) was administered to the left eye using a lens-sparing single lateral technique. She underwent craniotomy for cere-bellar hemangioblastoma at the age of 22 years and total pancreatectomy for multiple neuroendocrine tumors at the age of 24 years. In the 6-year follow-up period after the radiotherapy, the optic disc hemangioma gradually reduced in size and its activity remained low, allowing good central vision to be maintained. External beam radiation is recommended as a treatment option for the initial therapy for optic disc hemangioma.

Original languageEnglish
Pages (from-to)135-141
Number of pages7
JournalActa Medica Okayama
Volume65
Issue number2
Publication statusPublished - 2011

Fingerprint

von Hippel-Lindau Disease
Optic Disk
Radiotherapy
Hemangioma
Optics
Hemangioblastoma
Radiation
Radiation Dosage
Paraganglioma
Pancreatectomy
Neuroendocrine Tumors
Craniotomy
Pheochromocytoma
Retinal Detachment
Missense Mutation
Lenses
Dosimetry
Headache
Tumors
Genes

Keywords

  • External beam radiation radiotherapy
  • Optic disc hemangioma
  • Pancreatic neuroendocrine tumor
  • Pheochromocytoma
  • Retinal papillary
  • Von Hippel-Lindau disease

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Long-term effect of external beam radiotherapy of optic disc hemangioma in a patient with von hippel-lindau disease. / Matsuo, Toshihiko; Himei, Kengo; Ichimura, Kouichi; Yanai, Hiroyuki; Nose, Soichiro; Mimura, Tetsushige; Miyoshi, Yasuyuki; Tsushima, Tomoyasu.

In: Acta Medica Okayama, Vol. 65, No. 2, 2011, p. 135-141.

Research output: Contribution to journalArticle

Matsuo, T, Himei, K, Ichimura, K, Yanai, H, Nose, S, Mimura, T, Miyoshi, Y & Tsushima, T 2011, 'Long-term effect of external beam radiotherapy of optic disc hemangioma in a patient with von hippel-lindau disease', Acta Medica Okayama, vol. 65, no. 2, pp. 135-141.
Matsuo, Toshihiko ; Himei, Kengo ; Ichimura, Kouichi ; Yanai, Hiroyuki ; Nose, Soichiro ; Mimura, Tetsushige ; Miyoshi, Yasuyuki ; Tsushima, Tomoyasu. / Long-term effect of external beam radiotherapy of optic disc hemangioma in a patient with von hippel-lindau disease. In: Acta Medica Okayama. 2011 ; Vol. 65, No. 2. pp. 135-141.
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