Abstract
An 18-year-old woman with a 2-year history of hypertension and headache was diagnosed with nora-drenalin-secreting bilateral adrenal pheochromocytomas with paragangliomas in the background of von Hippel-Lindau disease with family histories and a missense mutation, 712C to T (Argl67Trp) in the VHL gene. She had optic disc hemangioma in the left eye which gradually enlarged and caused serous retinal detachment on the macula in one year. Low-dose external beam radiation (20 Gy) was administered to the left eye using a lens-sparing single lateral technique. She underwent craniotomy for cere-bellar hemangioblastoma at the age of 22 years and total pancreatectomy for multiple neuroendocrine tumors at the age of 24 years. In the 6-year follow-up period after the radiotherapy, the optic disc hemangioma gradually reduced in size and its activity remained low, allowing good central vision to be maintained. External beam radiation is recommended as a treatment option for the initial therapy for optic disc hemangioma.
| Original language | English |
|---|---|
| Pages (from-to) | 135-141 |
| Number of pages | 7 |
| Journal | Acta Medica Okayama |
| Volume | 65 |
| Issue number | 2 |
| Publication status | Published - 2011 |
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Keywords
- External beam radiation radiotherapy
- Optic disc hemangioma
- Pancreatic neuroendocrine tumor
- Pheochromocytoma
- Retinal papillary
- Von Hippel-Lindau disease
ASJC Scopus subject areas
- Medicine(all)
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Long-term effect of external beam radiotherapy of optic disc hemangioma in a patient with von hippel-lindau disease. / Matsuo, Toshihiko; Himei, Kengo; Ichimura, Kouichi; Yanai, Hiroyuki; Nose, Soichiro; Mimura, Tetsushige; Miyoshi, Yasuyuki; Tsushima, Tomoyasu.
In: Acta Medica Okayama, Vol. 65, No. 2, 2011, p. 135-141.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Long-term effect of external beam radiotherapy of optic disc hemangioma in a patient with von hippel-lindau disease
AU - Matsuo, Toshihiko
AU - Himei, Kengo
AU - Ichimura, Kouichi
AU - Yanai, Hiroyuki
AU - Nose, Soichiro
AU - Mimura, Tetsushige
AU - Miyoshi, Yasuyuki
AU - Tsushima, Tomoyasu
PY - 2011
Y1 - 2011
N2 - An 18-year-old woman with a 2-year history of hypertension and headache was diagnosed with nora-drenalin-secreting bilateral adrenal pheochromocytomas with paragangliomas in the background of von Hippel-Lindau disease with family histories and a missense mutation, 712C to T (Argl67Trp) in the VHL gene. She had optic disc hemangioma in the left eye which gradually enlarged and caused serous retinal detachment on the macula in one year. Low-dose external beam radiation (20 Gy) was administered to the left eye using a lens-sparing single lateral technique. She underwent craniotomy for cere-bellar hemangioblastoma at the age of 22 years and total pancreatectomy for multiple neuroendocrine tumors at the age of 24 years. In the 6-year follow-up period after the radiotherapy, the optic disc hemangioma gradually reduced in size and its activity remained low, allowing good central vision to be maintained. External beam radiation is recommended as a treatment option for the initial therapy for optic disc hemangioma.
AB - An 18-year-old woman with a 2-year history of hypertension and headache was diagnosed with nora-drenalin-secreting bilateral adrenal pheochromocytomas with paragangliomas in the background of von Hippel-Lindau disease with family histories and a missense mutation, 712C to T (Argl67Trp) in the VHL gene. She had optic disc hemangioma in the left eye which gradually enlarged and caused serous retinal detachment on the macula in one year. Low-dose external beam radiation (20 Gy) was administered to the left eye using a lens-sparing single lateral technique. She underwent craniotomy for cere-bellar hemangioblastoma at the age of 22 years and total pancreatectomy for multiple neuroendocrine tumors at the age of 24 years. In the 6-year follow-up period after the radiotherapy, the optic disc hemangioma gradually reduced in size and its activity remained low, allowing good central vision to be maintained. External beam radiation is recommended as a treatment option for the initial therapy for optic disc hemangioma.
KW - External beam radiation radiotherapy
KW - Optic disc hemangioma
KW - Pancreatic neuroendocrine tumor
KW - Pheochromocytoma
KW - Retinal papillary
KW - Von Hippel-Lindau disease
UR - http://www.scopus.com/inward/record.url?scp=79955714443&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79955714443&partnerID=8YFLogxK
M3 - Article
C2 - 21519372
AN - SCOPUS:79955714443
VL - 65
SP - 135
EP - 141
JO - Acta Medica Okayama
JF - Acta Medica Okayama
SN - 0386-300X
IS - 2
ER -