Abstract
An 18-year-old woman with a 2-year history of hypertension and headache was diagnosed with nora-drenalin-secreting bilateral adrenal pheochromocytomas with paragangliomas in the background of von Hippel-Lindau disease with family histories and a missense mutation, 712C to T (Argl67Trp) in the VHL gene. She had optic disc hemangioma in the left eye which gradually enlarged and caused serous retinal detachment on the macula in one year. Low-dose external beam radiation (20 Gy) was administered to the left eye using a lens-sparing single lateral technique. She underwent craniotomy for cere-bellar hemangioblastoma at the age of 22 years and total pancreatectomy for multiple neuroendocrine tumors at the age of 24 years. In the 6-year follow-up period after the radiotherapy, the optic disc hemangioma gradually reduced in size and its activity remained low, allowing good central vision to be maintained. External beam radiation is recommended as a treatment option for the initial therapy for optic disc hemangioma.
Original language | English |
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Pages (from-to) | 135-141 |
Number of pages | 7 |
Journal | Acta medica Okayama |
Volume | 65 |
Issue number | 2 |
Publication status | Published - 2011 |
Keywords
- External beam radiation radiotherapy
- Optic disc hemangioma
- Pancreatic neuroendocrine tumor
- Pheochromocytoma
- Retinal papillary
- Von Hippel-Lindau disease
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)