Long-term effect of external beam radiotherapy of optic disc hemangioma in a patient with von hippel-lindau disease

Toshihiko Matsuo, Kengo Himei, Kouichi Ichimura, Hiroyuki Yanaic, Soichiro Nose, Tetsushige Mimura, Yasuyuki Miyoshi, Tomoyasu Tsushima

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5 Citations (Scopus)

Abstract

An 18-year-old woman with a 2-year history of hypertension and headache was diagnosed with nora-drenalin-secreting bilateral adrenal pheochromocytomas with paragangliomas in the background of von Hippel-Lindau disease with family histories and a missense mutation, 712C to T (Argl67Trp) in the VHL gene. She had optic disc hemangioma in the left eye which gradually enlarged and caused serous retinal detachment on the macula in one year. Low-dose external beam radiation (20 Gy) was administered to the left eye using a lens-sparing single lateral technique. She underwent craniotomy for cere-bellar hemangioblastoma at the age of 22 years and total pancreatectomy for multiple neuroendocrine tumors at the age of 24 years. In the 6-year follow-up period after the radiotherapy, the optic disc hemangioma gradually reduced in size and its activity remained low, allowing good central vision to be maintained. External beam radiation is recommended as a treatment option for the initial therapy for optic disc hemangioma.

Original languageEnglish
Pages (from-to)135-141
Number of pages7
JournalActa medica Okayama
Volume65
Issue number2
Publication statusPublished - 2011

Keywords

  • External beam radiation radiotherapy
  • Optic disc hemangioma
  • Pancreatic neuroendocrine tumor
  • Pheochromocytoma
  • Retinal papillary
  • Von Hippel-Lindau disease

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Matsuo, T., Himei, K., Ichimura, K., Yanaic, H., Nose, S., Mimura, T., Miyoshi, Y., & Tsushima, T. (2011). Long-term effect of external beam radiotherapy of optic disc hemangioma in a patient with von hippel-lindau disease. Acta medica Okayama, 65(2), 135-141.