Long-term consequences of renal function following nephrectomy for renal cancer

Yoshinori Shirasaki, Tomoyasu Tsushima, Yasutomo Nasu, Hiromi Kumon

Research output: Contribution to journalReview articlepeer-review

33 Citations (Scopus)

Abstract

Aim: A retrospective analysis was performed involving patients who had undergone radical nephrectomy for renal cell cancer to determine the long-term outcome of this surgery on renal status. Materials and Methods: Between 1977 and 2001, 172 patients having undergone radical nephrectomy for renal cell cancer were followed for a period of more than one year at the Department of Urology Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan. The preoperative and postoperative serum creatinine values of these individuals were reviewed. Long-term effects of radical nephrectomy on renal function and factors influencing postoperative renal dysfunction were analyzed. Results: Six (3.5%) of the 172 individuals progressed to hemodialysis. Eleven (6.4%) patients displayed serum creatinine values of ≥1.6 mg/dL. The remaining 155 patients (90.1%) demonstrated postoperative serum creatinine values of <1.6 mg/dL. The present study suggests that aging, a high degree of proteinuria, hypertension and diabetes mellitus were the predominant risk factors for renal deterioration following nephrectomy. Conclusions: We have primarily selected radical nephrectomy for cases exhibiting smaller renal tumors with a normal contralateral kidney. We encourage nephron-sparing surgery where possible in patients displaying risk factors, including a high degree of proteinuria, hypertension, or diabetes mellitus.

Original languageEnglish
Pages (from-to)704-708
Number of pages5
JournalInternational Journal of Urology
Volume11
Issue number9
DOIs
Publication statusPublished - Sep 2004

Keywords

  • Nephrectomy
  • Renal cell cancer
  • Renal function

ASJC Scopus subject areas

  • Urology

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