Long-term consequences of Kawasaki disease: A 10- to 21-year follow-up study of 594 patients

Hirohisa Kato, Tetsu Sugimura, Teiji Akagi, Noboru Sato, Kanoko Hashino, Yasuki Maeno, Takeyo Kazue, Genzyu Eto, Rumi Yamakawa

Research output: Contribution to journalArticle

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Abstract

Background: The long-term consequences of the cardiovascular sequence in Kawasaki disease remain uncertain. Methods and Results: We identified 594 consecutive children with acute Kawasaki disease between 1973 and 1983, and this cohort was followed up for 10 to 21 years (mean, 13.6 years). In all patients, we evaluated coronary lesions by coronary angiography just after the acute stage. One hundred and forty-six patients (24.6%) were diagnosed as having coronary aneurysms. A second angiogram was performed 1 to 2 years later in all 146 patients who previously had coronary aneurysms, which demonstrated that 72 (49.3%) of these 146 had regression in the coronary aneurysm. A third angiogram was performed for 62 patients, a fourth for 29, and fifth for 17. By 10 to 21 years after the onset of the illness, stenosis in the coronary aneurysm had developed in 28 patients. Myocardial infarction occurred in 11 patients, 5 of whom died. In the 26 patients with giant coronary aneurysms, stenotic lesions developed in 12, and no regression occurred. The 448 patients with normal findings at the first angiogram subsequently never developed any abnormal cardiac findings. Systematic artery aneurysms developed in 13 patients (2.2%), and valvular heart disease appeared in 7 (1.2%) Conclusions: The incidence of coronary aneurysm in acute Kawasaki disease was 25%, 55% of which showed regression. During follow-up, ischemic heart disease developed in 4.7% and myocardial infarction in 1.9%. Death occurred in 0.8%.

Original languageEnglish
Pages (from-to)1379-1385
Number of pages7
JournalCirculation
Volume94
Issue number6
Publication statusPublished - 1996
Externally publishedYes

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Mucocutaneous Lymph Node Syndrome
antineoplaston A10
Coronary Aneurysm
Angiography
Acute Disease
Myocardial Infarction
Heart Valve Diseases
Coronary Angiography
Myocardial Ischemia
Aneurysm
Pathologic Constriction
Arteries
Incidence

Keywords

  • aneurysm
  • coronary disease
  • Kawasaki disease
  • myocardial infarction
  • valves

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Kato, H., Sugimura, T., Akagi, T., Sato, N., Hashino, K., Maeno, Y., ... Yamakawa, R. (1996). Long-term consequences of Kawasaki disease: A 10- to 21-year follow-up study of 594 patients. Circulation, 94(6), 1379-1385.

Long-term consequences of Kawasaki disease : A 10- to 21-year follow-up study of 594 patients. / Kato, Hirohisa; Sugimura, Tetsu; Akagi, Teiji; Sato, Noboru; Hashino, Kanoko; Maeno, Yasuki; Kazue, Takeyo; Eto, Genzyu; Yamakawa, Rumi.

In: Circulation, Vol. 94, No. 6, 1996, p. 1379-1385.

Research output: Contribution to journalArticle

Kato, H, Sugimura, T, Akagi, T, Sato, N, Hashino, K, Maeno, Y, Kazue, T, Eto, G & Yamakawa, R 1996, 'Long-term consequences of Kawasaki disease: A 10- to 21-year follow-up study of 594 patients', Circulation, vol. 94, no. 6, pp. 1379-1385.
Kato H, Sugimura T, Akagi T, Sato N, Hashino K, Maeno Y et al. Long-term consequences of Kawasaki disease: A 10- to 21-year follow-up study of 594 patients. Circulation. 1996;94(6):1379-1385.
Kato, Hirohisa ; Sugimura, Tetsu ; Akagi, Teiji ; Sato, Noboru ; Hashino, Kanoko ; Maeno, Yasuki ; Kazue, Takeyo ; Eto, Genzyu ; Yamakawa, Rumi. / Long-term consequences of Kawasaki disease : A 10- to 21-year follow-up study of 594 patients. In: Circulation. 1996 ; Vol. 94, No. 6. pp. 1379-1385.
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AU - Sato, Noboru

AU - Hashino, Kanoko

AU - Maeno, Yasuki

AU - Kazue, Takeyo

AU - Eto, Genzyu

AU - Yamakawa, Rumi

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N2 - Background: The long-term consequences of the cardiovascular sequence in Kawasaki disease remain uncertain. Methods and Results: We identified 594 consecutive children with acute Kawasaki disease between 1973 and 1983, and this cohort was followed up for 10 to 21 years (mean, 13.6 years). In all patients, we evaluated coronary lesions by coronary angiography just after the acute stage. One hundred and forty-six patients (24.6%) were diagnosed as having coronary aneurysms. A second angiogram was performed 1 to 2 years later in all 146 patients who previously had coronary aneurysms, which demonstrated that 72 (49.3%) of these 146 had regression in the coronary aneurysm. A third angiogram was performed for 62 patients, a fourth for 29, and fifth for 17. By 10 to 21 years after the onset of the illness, stenosis in the coronary aneurysm had developed in 28 patients. Myocardial infarction occurred in 11 patients, 5 of whom died. In the 26 patients with giant coronary aneurysms, stenotic lesions developed in 12, and no regression occurred. The 448 patients with normal findings at the first angiogram subsequently never developed any abnormal cardiac findings. Systematic artery aneurysms developed in 13 patients (2.2%), and valvular heart disease appeared in 7 (1.2%) Conclusions: The incidence of coronary aneurysm in acute Kawasaki disease was 25%, 55% of which showed regression. During follow-up, ischemic heart disease developed in 4.7% and myocardial infarction in 1.9%. Death occurred in 0.8%.

AB - Background: The long-term consequences of the cardiovascular sequence in Kawasaki disease remain uncertain. Methods and Results: We identified 594 consecutive children with acute Kawasaki disease between 1973 and 1983, and this cohort was followed up for 10 to 21 years (mean, 13.6 years). In all patients, we evaluated coronary lesions by coronary angiography just after the acute stage. One hundred and forty-six patients (24.6%) were diagnosed as having coronary aneurysms. A second angiogram was performed 1 to 2 years later in all 146 patients who previously had coronary aneurysms, which demonstrated that 72 (49.3%) of these 146 had regression in the coronary aneurysm. A third angiogram was performed for 62 patients, a fourth for 29, and fifth for 17. By 10 to 21 years after the onset of the illness, stenosis in the coronary aneurysm had developed in 28 patients. Myocardial infarction occurred in 11 patients, 5 of whom died. In the 26 patients with giant coronary aneurysms, stenotic lesions developed in 12, and no regression occurred. The 448 patients with normal findings at the first angiogram subsequently never developed any abnormal cardiac findings. Systematic artery aneurysms developed in 13 patients (2.2%), and valvular heart disease appeared in 7 (1.2%) Conclusions: The incidence of coronary aneurysm in acute Kawasaki disease was 25%, 55% of which showed regression. During follow-up, ischemic heart disease developed in 4.7% and myocardial infarction in 1.9%. Death occurred in 0.8%.

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