Long-term administration of adrenocorticotropin modulates the expression of IGF-I and TGF-β1 mRNAs in the rat adrenal cortex

Fumio Otsuka, Toshio Ogura, Takayoshi Yamauchi, Hideo Kataoka, Masayuki Kishida, Nobuyuki Miyatake, Yukari Mimura, Jingo Kageyama, Hirofumi Makino

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The effects of long-term adrenocorticotropin (ACTH) therapy on the expression of IGF-I and TGF-β1 on rat adrenal cortex was investigated. ACTH (0.1 mg/kg/day) or saline as control was injected intraperitoneally in 5- week-old Wistar rats every day for 4 weeks. ACTH significantly increased adrenal weight (P1 (P1 level (P1 mRNA levels and serum corticosterone concentration (P1 expression in the same area. Our results show that an increase in adrenocortical growth resulting from ACTH treatment is associated with an increase in IGF-I mRNA expression but only a transient increase in TGF-β1 mRNA expression.

Original languageEnglish
Pages (from-to)41-51
Number of pages11
JournalGrowth Hormone and IGF Research
Volume9
Issue number1
DOIs
Publication statusPublished - 1999

Fingerprint

Adrenal Cortex
Insulin-Like Growth Factor I
Adrenocorticotropic Hormone
Messenger RNA
Corticosterone
Wistar Rats
Weights and Measures
Growth
Serum

Keywords

  • Adrenal cortex
  • Insulin-like growth factor-I
  • Proliferating cell nuclear antigen

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Long-term administration of adrenocorticotropin modulates the expression of IGF-I and TGF-β1 mRNAs in the rat adrenal cortex. / Otsuka, Fumio; Ogura, Toshio; Yamauchi, Takayoshi; Kataoka, Hideo; Kishida, Masayuki; Miyatake, Nobuyuki; Mimura, Yukari; Kageyama, Jingo; Makino, Hirofumi.

In: Growth Hormone and IGF Research, Vol. 9, No. 1, 1999, p. 41-51.

Research output: Contribution to journalArticle

Otsuka, Fumio ; Ogura, Toshio ; Yamauchi, Takayoshi ; Kataoka, Hideo ; Kishida, Masayuki ; Miyatake, Nobuyuki ; Mimura, Yukari ; Kageyama, Jingo ; Makino, Hirofumi. / Long-term administration of adrenocorticotropin modulates the expression of IGF-I and TGF-β1 mRNAs in the rat adrenal cortex. In: Growth Hormone and IGF Research. 1999 ; Vol. 9, No. 1. pp. 41-51.
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AU - Kishida, Masayuki

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