Long QT syndrome

Atsuyuki Watanabe, Kazufumi Nakamura, Hiroshi Morita, Kengo Fukushima Kusano, Tohru Ohe

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The long QT syndrome (LQTS) is characterized by prolongation of the QT interval, causing torsade de pointes and sudden cardiac death. This syndrome can be divided into idiopathic (congenital) and acquired forms. The idiopathic form is a familial disorder that can be associated with sensorineural deafness (Jervell and Lange--Nielsen syndrome, autosomal recessive) or normal hearing (Romano--Ward syndrome, autosomal dominant). The acquired form has a long QT interval caused by various drugs such as quinidine sotalol and dofetilide, also by noncardiovascular drugs such as antihistamine, antibiotics, antipsychotics and others. Also, the QT interval is prolonged by electrolyte abnormalities such as hypokalemia and hypomagnesemia, central nervous system lesions, significant bradyarrhythmias, cardiac ganglionitis, mitral valve prolapse and probucol. DNA variants appearing to predispose to drug-associated acquired long QT syndrome have been reported in congenital long QT.

Original languageEnglish
Pages (from-to)1171-1177
Number of pages7
JournalNihon rinsho. Japanese journal of clinical medicine
Volume63
Issue number7
Publication statusPublished - 2005

Fingerprint

Long QT Syndrome
Jervell-Lange Nielsen Syndrome
Romano-Ward Syndrome
Pharmaceutical Preparations
Probucol
Sotalol
Torsades de Pointes
Mitral Valve Prolapse
Quinidine
Hypokalemia
Histamine Antagonists
Sudden Cardiac Death
Deafness
Bradycardia
Electrolytes
Antipsychotic Agents
Hearing
Central Nervous System
Anti-Bacterial Agents
DNA

Cite this

Long QT syndrome. / Watanabe, Atsuyuki; Nakamura, Kazufumi; Morita, Hiroshi; Kusano, Kengo Fukushima; Ohe, Tohru.

In: Nihon rinsho. Japanese journal of clinical medicine, Vol. 63, No. 7, 2005, p. 1171-1177.

Research output: Contribution to journalArticle

Watanabe, Atsuyuki ; Nakamura, Kazufumi ; Morita, Hiroshi ; Kusano, Kengo Fukushima ; Ohe, Tohru. / Long QT syndrome. In: Nihon rinsho. Japanese journal of clinical medicine. 2005 ; Vol. 63, No. 7. pp. 1171-1177.
@article{36f88f2f71094ec1b7635b690372c300,
title = "Long QT syndrome",
abstract = "The long QT syndrome (LQTS) is characterized by prolongation of the QT interval, causing torsade de pointes and sudden cardiac death. This syndrome can be divided into idiopathic (congenital) and acquired forms. The idiopathic form is a familial disorder that can be associated with sensorineural deafness (Jervell and Lange--Nielsen syndrome, autosomal recessive) or normal hearing (Romano--Ward syndrome, autosomal dominant). The acquired form has a long QT interval caused by various drugs such as quinidine sotalol and dofetilide, also by noncardiovascular drugs such as antihistamine, antibiotics, antipsychotics and others. Also, the QT interval is prolonged by electrolyte abnormalities such as hypokalemia and hypomagnesemia, central nervous system lesions, significant bradyarrhythmias, cardiac ganglionitis, mitral valve prolapse and probucol. DNA variants appearing to predispose to drug-associated acquired long QT syndrome have been reported in congenital long QT.",
author = "Atsuyuki Watanabe and Kazufumi Nakamura and Hiroshi Morita and Kusano, {Kengo Fukushima} and Tohru Ohe",
year = "2005",
language = "English",
volume = "63",
pages = "1171--1177",
journal = "Nippon rinsho. Japanese journal of clinical medicine",
issn = "0047-1852",
publisher = "Nipponrinsho Co., Inc.",
number = "7",

}

TY - JOUR

T1 - Long QT syndrome

AU - Watanabe, Atsuyuki

AU - Nakamura, Kazufumi

AU - Morita, Hiroshi

AU - Kusano, Kengo Fukushima

AU - Ohe, Tohru

PY - 2005

Y1 - 2005

N2 - The long QT syndrome (LQTS) is characterized by prolongation of the QT interval, causing torsade de pointes and sudden cardiac death. This syndrome can be divided into idiopathic (congenital) and acquired forms. The idiopathic form is a familial disorder that can be associated with sensorineural deafness (Jervell and Lange--Nielsen syndrome, autosomal recessive) or normal hearing (Romano--Ward syndrome, autosomal dominant). The acquired form has a long QT interval caused by various drugs such as quinidine sotalol and dofetilide, also by noncardiovascular drugs such as antihistamine, antibiotics, antipsychotics and others. Also, the QT interval is prolonged by electrolyte abnormalities such as hypokalemia and hypomagnesemia, central nervous system lesions, significant bradyarrhythmias, cardiac ganglionitis, mitral valve prolapse and probucol. DNA variants appearing to predispose to drug-associated acquired long QT syndrome have been reported in congenital long QT.

AB - The long QT syndrome (LQTS) is characterized by prolongation of the QT interval, causing torsade de pointes and sudden cardiac death. This syndrome can be divided into idiopathic (congenital) and acquired forms. The idiopathic form is a familial disorder that can be associated with sensorineural deafness (Jervell and Lange--Nielsen syndrome, autosomal recessive) or normal hearing (Romano--Ward syndrome, autosomal dominant). The acquired form has a long QT interval caused by various drugs such as quinidine sotalol and dofetilide, also by noncardiovascular drugs such as antihistamine, antibiotics, antipsychotics and others. Also, the QT interval is prolonged by electrolyte abnormalities such as hypokalemia and hypomagnesemia, central nervous system lesions, significant bradyarrhythmias, cardiac ganglionitis, mitral valve prolapse and probucol. DNA variants appearing to predispose to drug-associated acquired long QT syndrome have been reported in congenital long QT.

UR - http://www.scopus.com/inward/record.url?scp=23844448083&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23844448083&partnerID=8YFLogxK

M3 - Article

VL - 63

SP - 1171

EP - 1177

JO - Nippon rinsho. Japanese journal of clinical medicine

JF - Nippon rinsho. Japanese journal of clinical medicine

SN - 0047-1852

IS - 7

ER -