Long-Lasting Immune Response Induced by Recombinant Bacillus Calmette-Guérin (BCG) Secretion System

N. Wada, N. Ohara, M. Kameoka, Y. Nishino, S. Matsumoto, T. Nishiyama, M. Naito, H. Yukitake, Y. Okada, K. Ikuta, T. Yamada

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Abstract

The recombinant bacillus Calmette-Guérin (rBCG) secretion system utilizing an extracellular α antigen of Mycobacterium kansasii (α-K) was characterized biochemically and immunologically. The human immunodeficiency virus type1 (HIV-1) p17gag B cell epitope fused to α-K was secreted in extremely large amounts. At least three mice out of seven inoculated with rBCG generated high titres of antibody to the epitope. The long-lasting antibody production persisted more than 14 months.

Original languageEnglish
Pages (from-to)202-209
Number of pages8
JournalScandinavian Journal of Immunology
Volume43
Issue number2
DOIs
Publication statusPublished - Jan 1 1996
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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    Wada, N., Ohara, N., Kameoka, M., Nishino, Y., Matsumoto, S., Nishiyama, T., Naito, M., Yukitake, H., Okada, Y., Ikuta, K., & Yamada, T. (1996). Long-Lasting Immune Response Induced by Recombinant Bacillus Calmette-Guérin (BCG) Secretion System. Scandinavian Journal of Immunology, 43(2), 202-209. https://doi.org/10.1046/j.1365-3083.1996.d01-28.x