Long-Lasting Immune Response Induced by Recombinant Bacillus Calmette-Guérin (BCG) Secretion System

N. Wada; N. Ohara; M. Kameoka; Y. Nishino; S. Matsumoto; T. Nishiyama; M. Naito; H. Yukitake; Y. Okada; K. Ikuta; T. Yamada

doi:10.1046/j.1365-3083.1996.d01-28.x

Long-Lasting Immune Response Induced by Recombinant Bacillus Calmette-Guérin (BCG) Secretion System

N. Wada, N. Ohara, M. Kameoka, Y. Nishino, S. Matsumoto, T. Nishiyama, M. Naito, H. Yukitake, Y. Okada, K. Ikuta, T. Yamada

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

The recombinant bacillus Calmette-Guérin (rBCG) secretion system utilizing an extracellular α antigen of Mycobacterium kansasii (α-K) was characterized biochemically and immunologically. The human immunodeficiency virus type1 (HIV-1) p17^gag B cell epitope fused to α-K was secreted in extremely large amounts. At least three mice out of seven inoculated with rBCG generated high titres of antibody to the epitope. The long-lasting antibody production persisted more than 14 months.

Original language	English
Pages (from-to)	202-209
Number of pages	8
Journal	Scandinavian Journal of Immunology
Volume	43
Issue number	2
DOIs	https://doi.org/10.1046/j.1365-3083.1996.d01-28.x
Publication status	Published - Jan 1 1996
Externally published	Yes

ASJC Scopus subject areas

Immunology

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Long-Lasting Immune Response Induced by Recombinant Bacillus Calmette-Guérin (BCG) Secretion System. / Wada, N.; Ohara, N.; Kameoka, M.; Nishino, Y.; Matsumoto, S.; Nishiyama, T.; Naito, M.; Yukitake, H.; Okada, Y.; Ikuta, K.; Yamada, T.

In: Scandinavian Journal of Immunology, Vol. 43, No. 2, 01.01.1996, p. 202-209.

Research output: Contribution to journal › Article › peer-review

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