Long-Lasting Immune Response Induced by Recombinant Bacillus Calmette-Guérin (BCG) Secretion System

N. Wada, Naoya Oohara, M. Kameoka, Y. Nishino, S. Matsumoto, T. Nishiyama, M. Naito, H. Yukitake, Y. Okada, K. Ikuta, T. Yamada

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The recombinant bacillus Calmette-Guérin (rBCG) secretion system utilizing an extracellular α antigen of Mycobacterium kansasii (α-K) was characterized biochemically and immunologically. The human immunodeficiency virus type1 (HIV-1) p17gag B cell epitope fused to α-K was secreted in extremely large amounts. At least three mice out of seven inoculated with rBCG generated high titres of antibody to the epitope. The long-lasting antibody production persisted more than 14 months.

Original languageEnglish
Pages (from-to)202-209
Number of pages8
JournalScandinavian Journal of Immunology
Volume43
Issue number2
Publication statusPublished - 1996
Externally publishedYes

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Bacillus
Mycobacterium kansasii
B-Lymphocyte Epitopes
Antibody Formation
Epitopes
HIV
Antigens
Antibodies

ASJC Scopus subject areas

  • Immunology

Cite this

Wada, N., Oohara, N., Kameoka, M., Nishino, Y., Matsumoto, S., Nishiyama, T., ... Yamada, T. (1996). Long-Lasting Immune Response Induced by Recombinant Bacillus Calmette-Guérin (BCG) Secretion System. Scandinavian Journal of Immunology, 43(2), 202-209.

Long-Lasting Immune Response Induced by Recombinant Bacillus Calmette-Guérin (BCG) Secretion System. / Wada, N.; Oohara, Naoya; Kameoka, M.; Nishino, Y.; Matsumoto, S.; Nishiyama, T.; Naito, M.; Yukitake, H.; Okada, Y.; Ikuta, K.; Yamada, T.

In: Scandinavian Journal of Immunology, Vol. 43, No. 2, 1996, p. 202-209.

Research output: Contribution to journalArticle

Wada, N, Oohara, N, Kameoka, M, Nishino, Y, Matsumoto, S, Nishiyama, T, Naito, M, Yukitake, H, Okada, Y, Ikuta, K & Yamada, T 1996, 'Long-Lasting Immune Response Induced by Recombinant Bacillus Calmette-Guérin (BCG) Secretion System', Scandinavian Journal of Immunology, vol. 43, no. 2, pp. 202-209.
Wada, N. ; Oohara, Naoya ; Kameoka, M. ; Nishino, Y. ; Matsumoto, S. ; Nishiyama, T. ; Naito, M. ; Yukitake, H. ; Okada, Y. ; Ikuta, K. ; Yamada, T. / Long-Lasting Immune Response Induced by Recombinant Bacillus Calmette-Guérin (BCG) Secretion System. In: Scandinavian Journal of Immunology. 1996 ; Vol. 43, No. 2. pp. 202-209.
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