Locally injected ivabradine inhibits carrageenan-induced pain and inflammatory responses via hyperpolarization-activated cyclic nucleotide-gated (HCN) channels

Medicine & Life Sciences

• Ivabradine 79%
• Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels 79%
• Carrageenan 61%
• Pain 30%
• Pain Threshold 22%
• Tumor Necrosis Factor-alpha 13%
• Neuralgia 9%
• Leukocytes 7%
• Lamotrigine 6%
• Colforsin 5%
• Subcutaneous Injections 4%
• Peripheral Nerves 4%
• Sprague Dawley Rats 4%
• Anti-Inflammatory Agents 3%
• Animal Models 3%
• Macrophages 3%
• Inflammation 2%
• Injections 2%
• In Vitro Techniques 2%
• Therapeutics 0%

Agriculture & Biology

• cyclic nucleotides 60%
• carrageenan 60%
• pain 54%
• inflammation 47%
• tumor necrosis factor-alpha 20%
• leukocytes 11%
• rats 10%
• peripheral nerves 8%
• forskolin 7%
• subcutaneous injection 7%
• anti-inflammatory activity 6%
• in vitro studies 6%
• macrophages 5%
• animal models 5%
• injection 4%
• cells 4%
• mice 3%
• methodology 1%

Chemical Compounds

• Ivabradine 100%
• Carrageenan 24%
• Lamotrigine 7%
• Forskolin 6%
• Filament 4%
• Antiinflammatory 4%