Abstract
The metallothionein (MT) family is a class of low molecular, intracellular, and cysteine-rich proteins with a high affinity for metals. Although the first of these proteins was discovered nearly 40 years ago, their functional significance remains obscure. Four major isoforms (MT-I, MT-II, MT-III, and MT-IV) have been identified in mammals. MT-I and MT-II are ubiquitously expressed in varjous organs including the brain, while expression of MT-III and MT-IV is restricted in specific organs. MT-III was detected predominantly in the brain, and characterized as a central nervous system-specific isomer. The role of MTs in the central nervous system has become an intense focus of scientific research. An isomer of MTs, MT-III, of particular interest, was originally discovered as a growth inhibitory factor, and has been found to be markedly reduced in the brain of patients with Alzheimer's disease and several other neurodegenerative diseases. MT-III fulfills unique biological roles in homeostasis of the central nervous system and in the etiology of neuropathological disorders.
| Original language | English |
|---|---|
| Pages (from-to) | 1-9 |
| Number of pages | 9 |
| Journal | Acta Medica Okayama |
| Volume | 55 |
| Issue number | 1 |
| Publication status | Published - 2001 |
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Keywords
- Gene expression
- Localization
- Metal transport
- Neurodegenerative disease
- Neuroprotectin
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
Localization, regulation, and function of metallothionein-III/growth inhibitory factor in the brain. / Sogawa, Chiharu; Asanuma, Masato; Sogawa, Norio; Miyazaki, Ikuko; Nakanishi, Tohru; Furuta, Hiroaki; Ogawa, Norio.
In: Acta Medica Okayama, Vol. 55, No. 1, 2001, p. 1-9.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Localization, regulation, and function of metallothionein-III/growth inhibitory factor in the brain
AU - Sogawa, Chiharu
AU - Asanuma, Masato
AU - Sogawa, Norio
AU - Miyazaki, Ikuko
AU - Nakanishi, Tohru
AU - Furuta, Hiroaki
AU - Ogawa, Norio
PY - 2001
Y1 - 2001
N2 - The metallothionein (MT) family is a class of low molecular, intracellular, and cysteine-rich proteins with a high affinity for metals. Although the first of these proteins was discovered nearly 40 years ago, their functional significance remains obscure. Four major isoforms (MT-I, MT-II, MT-III, and MT-IV) have been identified in mammals. MT-I and MT-II are ubiquitously expressed in varjous organs including the brain, while expression of MT-III and MT-IV is restricted in specific organs. MT-III was detected predominantly in the brain, and characterized as a central nervous system-specific isomer. The role of MTs in the central nervous system has become an intense focus of scientific research. An isomer of MTs, MT-III, of particular interest, was originally discovered as a growth inhibitory factor, and has been found to be markedly reduced in the brain of patients with Alzheimer's disease and several other neurodegenerative diseases. MT-III fulfills unique biological roles in homeostasis of the central nervous system and in the etiology of neuropathological disorders.
AB - The metallothionein (MT) family is a class of low molecular, intracellular, and cysteine-rich proteins with a high affinity for metals. Although the first of these proteins was discovered nearly 40 years ago, their functional significance remains obscure. Four major isoforms (MT-I, MT-II, MT-III, and MT-IV) have been identified in mammals. MT-I and MT-II are ubiquitously expressed in varjous organs including the brain, while expression of MT-III and MT-IV is restricted in specific organs. MT-III was detected predominantly in the brain, and characterized as a central nervous system-specific isomer. The role of MTs in the central nervous system has become an intense focus of scientific research. An isomer of MTs, MT-III, of particular interest, was originally discovered as a growth inhibitory factor, and has been found to be markedly reduced in the brain of patients with Alzheimer's disease and several other neurodegenerative diseases. MT-III fulfills unique biological roles in homeostasis of the central nervous system and in the etiology of neuropathological disorders.
KW - Gene expression
KW - Localization
KW - Metal transport
KW - Neurodegenerative disease
KW - Neuroprotectin
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UR - http://www.scopus.com/inward/citedby.url?scp=0035260711&partnerID=8YFLogxK
M3 - Article
C2 - 11246971
AN - SCOPUS:0035260711
VL - 55
SP - 1
EP - 9
JO - Acta Medica Okayama
JF - Acta Medica Okayama
SN - 0386-300X
IS - 1
ER -