Localization of the locus responsible for Chediak-Higashi syndrome in cattle to bovine chromosome 28

Tetsuo Kunieda, H. Ide, M. Nakagiri, K. Yoneda, B. Konfortov, H. Ogawa

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Chediak-Higashi syndrome in Japanese black cattle is a hereditary disease with prolonged bleeding time and partial albinism. In the present study, we mapped the locus responsible for the disease (CHS) by linkage analysis using microsatellite genotypes of paternal half-sib pedigrees obtained from commercial herds. Analysis revealed significant linkage between the CHS locus and marker loci on the proximal end of bovine chromosome 28. The CHS locus was mapped on the region incorporating the microsatellite markers BMC6020, BM2892. and RM016 with recombination fraction 0 and lod score 4 · 9-11 · 2. We also assigned the bovine CHS1/LYST, the homologue of the gene responsible for human Chediak-Higashi syndrome, to bovine chromosome 28 using a bovine/murine somatic cell hybrid panel. These findings suggest that a mutation in the CHS1/LYST gene is likely to be responsible for Chediak-Higashi syndrome in Japanese black cattle.

Original languageEnglish
Pages (from-to)87-90
Number of pages4
JournalAnimal Genetics
Issue number2
Publication statusPublished - Apr 2000



  • Cattle
  • Chediak-Higashi syndrome
  • Gene mapping
  • Linkage analysis

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Genetics
  • Genetics(clinical)

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