Localization of receptors for atrial natriuretic polypeptide (ANP) in the glomerulus: in vitro electron microscopic autoradiographical investigation using 125I-labeled ANP

Kiminao Mizukawa, Toshiro Ogura, Ichiro Yamamoto, Takeshi Mitsui, Eriko Katayama, Zensuke Ota, Norio Ogawa

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The localization of receptors for atrial natriuretic polypeptide (ANP) in the glomerulus of the rat was studied by electron microscopic autoradiography using 125I-labeled ANP. A total of 1,134 silver grains counted in 30 glomeruli were distributed as follows: processes of the podocytes (36.4%), cell bodies of the podocytes (14.8%), basement membrane (12.3%), endothelial cells (6.3%), mesangial cells (7.7%) and others, for example the vascular spaces (22.5%). This finding indicates that ANP binding sites are mainly localized on the foot processes of the podocytes in the glomerulus.

Original languageEnglish
Pages (from-to)167-172
Number of pages6
JournalRegulatory Peptides
Volume21
Issue number1-2
DOIs
Publication statusPublished - May 1988

Keywords

  • Atrial natriuretic polypeptide receptor
  • Glomerulus
  • In vitro autoradiography
  • Podocyte
  • Ultrastructure

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Clinical Biochemistry
  • Cellular and Molecular Neuroscience

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