Localization of oxytalan fiber, type iii collagen and bmp family in conventional and desmoplastic ameloblastoma

Masahisa Inoue, Hitoshi Nagatsuka, Ryo Tamamura, Chong Uuat Siar, Hidetsugu Tsujigiwa, Silvia Borkosky, M. Fujii, Noriyuki Nagai, Kojun Setsu

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The histologic hallmark distinguishing desmoplastic ameloblastoma (DA) from conventional ameloblastoma (CA) is its pronounced stromal desmoplasia, and this formed the basis of this investigation. To elucidate the stromal characteristics, localization patterns of oxytalan fibers, type III collagen and BMP family in DA (n=8) was compared with CA (n=24), and periodontal ligament (PL) («= 8). Oxytalan fibers formed apico-occlusal bundles in PL, thick radial bundles around tumor nests in DA, and as scanty fibers in CA. Type III collagen was identified in PL, strongly expressed in DA stroma, but weakly in CA. BMP-2, -3, 4 and -7 expression patterns in tumor epithelium and stroma were more pronounced in DA (including sites of bone formation), than CA. No immunoreactivity for BMP-5 and -6 were detected. Current findings suggest that the stroma in DA is neoplastic and derived from odontogenic ectomesenchyme, and recommends its reclassification as an odontogenic epithelial-ectomcsenchymal neoplasm.

Original languageEnglish
Pages (from-to)23-30
Number of pages8
JournalJournal of Hard Tissue Biology
Volume17
Issue number1
DOIs
Publication statusPublished - 2008

Fingerprint

Ameloblastoma
Ligaments
Collagen
Collagen Type III
Fibers
Tumors
Bone Morphogenetic Protein 5
Periodontal Ligament
Bone
oxytalan
Bone Morphogenetic Protein 6
Glandular and Epithelial Neoplasms
Osteogenesis
Neoplasms
Epithelium

Keywords

  • Ameloblastoma
  • Bmp family
  • Matrix proteins
  • Odontogenic neoplasm

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Biomaterials
  • Medicine (miscellaneous)
  • Orthopedics and Sports Medicine
  • Dentistry(all)

Cite this

Localization of oxytalan fiber, type iii collagen and bmp family in conventional and desmoplastic ameloblastoma. / Inoue, Masahisa; Nagatsuka, Hitoshi; Tamamura, Ryo; Siar, Chong Uuat; Tsujigiwa, Hidetsugu; Borkosky, Silvia; Fujii, M.; Nagai, Noriyuki; Setsu, Kojun.

In: Journal of Hard Tissue Biology, Vol. 17, No. 1, 2008, p. 23-30.

Research output: Contribution to journalArticle

Inoue, M, Nagatsuka, H, Tamamura, R, Siar, CU, Tsujigiwa, H, Borkosky, S, Fujii, M, Nagai, N & Setsu, K 2008, 'Localization of oxytalan fiber, type iii collagen and bmp family in conventional and desmoplastic ameloblastoma', Journal of Hard Tissue Biology, vol. 17, no. 1, pp. 23-30. https://doi.org/10.2485/jhtb.17.23
Inoue, Masahisa ; Nagatsuka, Hitoshi ; Tamamura, Ryo ; Siar, Chong Uuat ; Tsujigiwa, Hidetsugu ; Borkosky, Silvia ; Fujii, M. ; Nagai, Noriyuki ; Setsu, Kojun. / Localization of oxytalan fiber, type iii collagen and bmp family in conventional and desmoplastic ameloblastoma. In: Journal of Hard Tissue Biology. 2008 ; Vol. 17, No. 1. pp. 23-30.
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