Localization of fibril/microfibril and basement membrane collagens in diabetic glomerulosclerosis in type 2 diabetes

Hirofumi Makino, Kenichi Shikata, J. Wieslander, Jun Wada, N. Kashihara, K. Yoshioka, Z. Ota

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Collagen is one of the major components of the extracellular matrices of the kidney. Basement membrane collagen, type IV collagen, is the major component in normal glomeruli. Fibril and interstitial collagen such as type III collagen, type V collagen, and type VI collagen are minor components of glomerular extracellular matrices and are localized mainly in the interstitium. Diabetic glomerulosclerosis is characterized by the expansion of the glomerular mesangial matrix as well as by thickening of the glomerular basement membrane. In order to clarify the roles of these various types of collagen in the development of diabetic glumerulosclerosis, immunohistochemical studies were performed in kidney specimens from patients with Type 2 diabetes. Early glomerulosclerosis is characterized by expansion of mesangial matrix with basement membrane collagen. However, in later stages glomerulosclerosis is characterized by an increase in the minor collagen components, such as type V and type VI collagen or collagens not normally present, such as type III collagen. Mesangial cells are known to synthesize all these types of collagen. In diabetes, phenotypic change in mesangial cells might produce excess amounts of fibril and interstitial collagen such as type III, type V, and type VI collagen, thus, leading to glomerulosclerosis.

Original languageEnglish
Pages (from-to)304-311
Number of pages8
JournalDiabetic Medicine
Volume11
Issue number3
Publication statusPublished - 1994

Fingerprint

Microfibrils
Diabetic Nephropathies
Basement Membrane
Type 2 Diabetes Mellitus
Collagen
Collagen Type VI
Collagen Type V
Mesangial Cells
Extracellular Matrix
Kidney
Glomerular Basement Membrane
Collagen Type III
Collagen Type IV

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Localization of fibril/microfibril and basement membrane collagens in diabetic glomerulosclerosis in type 2 diabetes. / Makino, Hirofumi; Shikata, Kenichi; Wieslander, J.; Wada, Jun; Kashihara, N.; Yoshioka, K.; Ota, Z.

In: Diabetic Medicine, Vol. 11, No. 3, 1994, p. 304-311.

Research output: Contribution to journalArticle

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AU - Wada, Jun

AU - Kashihara, N.

AU - Yoshioka, K.

AU - Ota, Z.

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