Localization of FGFR-1 in axotomized and peripheral nerve transplanted ferret retina

Mei Zi Quan, Mitsuko Kosaka, Masami Watanabe, Yutaka Fukuda

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

RETINAL ganglion cells (RGCs) survive axotomy and regenerate their axons into the peripheral nerve graft in adult mammals. To understand the potential role of fibroblast growth factors (FGFs) in survival and regeneration of axotomized RGCs, we examined FGF receptor 1 (FGFR-1) localization in normal and PN grafted ferret retinas by immunohistochemistry in combination with retrograde labeling. Prominent expression of FGFR-1 was observed in outer plexiform layer and ganglion cell layer of normal ferret retina. In the ganglion cell layer, FGFR-1 immunoreactivity was detected in about 30% of RGCs, predominantly in large cells. In the PN grafted ferret retina, 90% of RGCs with regenerated axons expressed FGFR-1. Our findings suggest that FGFs may play an important role in the survival and axonal regeneration of RGCs of adult mammals.

Original languageEnglish
Pages (from-to)3903-3907
Number of pages5
JournalNeuroReport
Volume10
Issue number18
Publication statusPublished - Dec 16 1999
Externally publishedYes

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Keywords

  • Axonal regeneration
  • Ferret
  • FGFR-1
  • Peripheral nerve transplantation
  • RGC

ASJC Scopus subject areas

  • Neuroscience(all)

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