Localization of antimicrobial peptides human β-defensins in minor salivary glands with Sjögren's syndrome

Yoshihiro Kaneda, Tomoichiro Yamaai, Nobuyoshi Mizukawa, Hitoshi Nagatsuka, Eiki Yamachika, Mehmet Gunduz, Koichi Sawaki, Yuji Yamanishi, Masakazu Matsubara, Naoki Katase, Shin Takagi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Sjögren's syndrome is a common systemic autoimmune disease associated with inflammatory cells that infiltrate exocrine glands. The antimicrobial peptides human β-defensin-1, human β-defensin-2, and human β-defensin-3 are expressed in various human epithelial cells and in normal salivary glands. Antimicrobial peptides provide local protection against infection and participate in inflammatory responses. Because of the presence of inflammation, we hypothesized that human β-defensin expression in minor salivary glands may be increased in subjects with Sjögren's syndrome. However, the expression of human β-defensins 1 and 2 was decreased in salivary glands affected by Sjögren's syndrome in comparison with the human β-defensin expression patterns in salivary glands from normal subjects. In addition, the reduction in expression of human β-defensin-2 was greater than the reduction in expression of human β-defensin-1. The aforementioned result suggests that the reduction in expression of human β-defensin-2 may occur earlier than the reduction in expression of human β-defensin-1, which may lead to a greater decrease in human β-defensin-2 than in human β-defensin-1 during disease progression.

Original languageEnglish
Pages (from-to)506-510
Number of pages5
JournalEuropean Journal of Oral Sciences
Volume117
Issue number5
DOIs
Publication statusPublished - Oct 2009

Fingerprint

Minor Salivary Glands
Defensins
Peptides
Salivary Glands
Exocrine Glands
Autoimmune Diseases
Disease Progression

Keywords

  • Defensin
  • Minor salivary gland
  • Sjögren's syndrome

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Localization of antimicrobial peptides human β-defensins in minor salivary glands with Sjögren's syndrome. / Kaneda, Yoshihiro; Yamaai, Tomoichiro; Mizukawa, Nobuyoshi; Nagatsuka, Hitoshi; Yamachika, Eiki; Gunduz, Mehmet; Sawaki, Koichi; Yamanishi, Yuji; Matsubara, Masakazu; Katase, Naoki; Takagi, Shin.

In: European Journal of Oral Sciences, Vol. 117, No. 5, 10.2009, p. 506-510.

Research output: Contribution to journalArticle

Kaneda, Yoshihiro ; Yamaai, Tomoichiro ; Mizukawa, Nobuyoshi ; Nagatsuka, Hitoshi ; Yamachika, Eiki ; Gunduz, Mehmet ; Sawaki, Koichi ; Yamanishi, Yuji ; Matsubara, Masakazu ; Katase, Naoki ; Takagi, Shin. / Localization of antimicrobial peptides human β-defensins in minor salivary glands with Sjögren's syndrome. In: European Journal of Oral Sciences. 2009 ; Vol. 117, No. 5. pp. 506-510.
@article{8bce63a57df04dc0868f4e937c8d3f60,
title = "Localization of antimicrobial peptides human β-defensins in minor salivary glands with Sj{\"o}gren's syndrome",
abstract = "Sj{\"o}gren's syndrome is a common systemic autoimmune disease associated with inflammatory cells that infiltrate exocrine glands. The antimicrobial peptides human β-defensin-1, human β-defensin-2, and human β-defensin-3 are expressed in various human epithelial cells and in normal salivary glands. Antimicrobial peptides provide local protection against infection and participate in inflammatory responses. Because of the presence of inflammation, we hypothesized that human β-defensin expression in minor salivary glands may be increased in subjects with Sj{\"o}gren's syndrome. However, the expression of human β-defensins 1 and 2 was decreased in salivary glands affected by Sj{\"o}gren's syndrome in comparison with the human β-defensin expression patterns in salivary glands from normal subjects. In addition, the reduction in expression of human β-defensin-2 was greater than the reduction in expression of human β-defensin-1. The aforementioned result suggests that the reduction in expression of human β-defensin-2 may occur earlier than the reduction in expression of human β-defensin-1, which may lead to a greater decrease in human β-defensin-2 than in human β-defensin-1 during disease progression.",
keywords = "Defensin, Minor salivary gland, Sj{\"o}gren's syndrome",
author = "Yoshihiro Kaneda and Tomoichiro Yamaai and Nobuyoshi Mizukawa and Hitoshi Nagatsuka and Eiki Yamachika and Mehmet Gunduz and Koichi Sawaki and Yuji Yamanishi and Masakazu Matsubara and Naoki Katase and Shin Takagi",
year = "2009",
month = "10",
doi = "10.1111/j.1600-0722.2009.00667.x",
language = "English",
volume = "117",
pages = "506--510",
journal = "European Journal of Oral Sciences",
issn = "0909-8836",
publisher = "Blackwell Munksgaard",
number = "5",

}

TY - JOUR

T1 - Localization of antimicrobial peptides human β-defensins in minor salivary glands with Sjögren's syndrome

AU - Kaneda, Yoshihiro

AU - Yamaai, Tomoichiro

AU - Mizukawa, Nobuyoshi

AU - Nagatsuka, Hitoshi

AU - Yamachika, Eiki

AU - Gunduz, Mehmet

AU - Sawaki, Koichi

AU - Yamanishi, Yuji

AU - Matsubara, Masakazu

AU - Katase, Naoki

AU - Takagi, Shin

PY - 2009/10

Y1 - 2009/10

N2 - Sjögren's syndrome is a common systemic autoimmune disease associated with inflammatory cells that infiltrate exocrine glands. The antimicrobial peptides human β-defensin-1, human β-defensin-2, and human β-defensin-3 are expressed in various human epithelial cells and in normal salivary glands. Antimicrobial peptides provide local protection against infection and participate in inflammatory responses. Because of the presence of inflammation, we hypothesized that human β-defensin expression in minor salivary glands may be increased in subjects with Sjögren's syndrome. However, the expression of human β-defensins 1 and 2 was decreased in salivary glands affected by Sjögren's syndrome in comparison with the human β-defensin expression patterns in salivary glands from normal subjects. In addition, the reduction in expression of human β-defensin-2 was greater than the reduction in expression of human β-defensin-1. The aforementioned result suggests that the reduction in expression of human β-defensin-2 may occur earlier than the reduction in expression of human β-defensin-1, which may lead to a greater decrease in human β-defensin-2 than in human β-defensin-1 during disease progression.

AB - Sjögren's syndrome is a common systemic autoimmune disease associated with inflammatory cells that infiltrate exocrine glands. The antimicrobial peptides human β-defensin-1, human β-defensin-2, and human β-defensin-3 are expressed in various human epithelial cells and in normal salivary glands. Antimicrobial peptides provide local protection against infection and participate in inflammatory responses. Because of the presence of inflammation, we hypothesized that human β-defensin expression in minor salivary glands may be increased in subjects with Sjögren's syndrome. However, the expression of human β-defensins 1 and 2 was decreased in salivary glands affected by Sjögren's syndrome in comparison with the human β-defensin expression patterns in salivary glands from normal subjects. In addition, the reduction in expression of human β-defensin-2 was greater than the reduction in expression of human β-defensin-1. The aforementioned result suggests that the reduction in expression of human β-defensin-2 may occur earlier than the reduction in expression of human β-defensin-1, which may lead to a greater decrease in human β-defensin-2 than in human β-defensin-1 during disease progression.

KW - Defensin

KW - Minor salivary gland

KW - Sjögren's syndrome

UR - http://www.scopus.com/inward/record.url?scp=70349202231&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70349202231&partnerID=8YFLogxK

U2 - 10.1111/j.1600-0722.2009.00667.x

DO - 10.1111/j.1600-0722.2009.00667.x

M3 - Article

C2 - 19758245

AN - SCOPUS:70349202231

VL - 117

SP - 506

EP - 510

JO - European Journal of Oral Sciences

JF - European Journal of Oral Sciences

SN - 0909-8836

IS - 5

ER -