TY - JOUR
T1 - Localization of antimicrobial peptides human β-defensins in minor salivary glands with Sjögren's syndrome
AU - Kaneda, Yoshihiro
AU - Yamaai, Tomoichiro
AU - Mizukawa, Nobuyoshi
AU - Nagatsuka, Hitoshi
AU - Yamachika, Eiki
AU - Gunduz, Mehmet
AU - Sawaki, Koichi
AU - Yamanishi, Yuji
AU - Matsubara, Masakazu
AU - Katase, Naoki
AU - Takagi, Shin
PY - 2009/10
Y1 - 2009/10
N2 - Sjögren's syndrome is a common systemic autoimmune disease associated with inflammatory cells that infiltrate exocrine glands. The antimicrobial peptides human β-defensin-1, human β-defensin-2, and human β-defensin-3 are expressed in various human epithelial cells and in normal salivary glands. Antimicrobial peptides provide local protection against infection and participate in inflammatory responses. Because of the presence of inflammation, we hypothesized that human β-defensin expression in minor salivary glands may be increased in subjects with Sjögren's syndrome. However, the expression of human β-defensins 1 and 2 was decreased in salivary glands affected by Sjögren's syndrome in comparison with the human β-defensin expression patterns in salivary glands from normal subjects. In addition, the reduction in expression of human β-defensin-2 was greater than the reduction in expression of human β-defensin-1. The aforementioned result suggests that the reduction in expression of human β-defensin-2 may occur earlier than the reduction in expression of human β-defensin-1, which may lead to a greater decrease in human β-defensin-2 than in human β-defensin-1 during disease progression.
AB - Sjögren's syndrome is a common systemic autoimmune disease associated with inflammatory cells that infiltrate exocrine glands. The antimicrobial peptides human β-defensin-1, human β-defensin-2, and human β-defensin-3 are expressed in various human epithelial cells and in normal salivary glands. Antimicrobial peptides provide local protection against infection and participate in inflammatory responses. Because of the presence of inflammation, we hypothesized that human β-defensin expression in minor salivary glands may be increased in subjects with Sjögren's syndrome. However, the expression of human β-defensins 1 and 2 was decreased in salivary glands affected by Sjögren's syndrome in comparison with the human β-defensin expression patterns in salivary glands from normal subjects. In addition, the reduction in expression of human β-defensin-2 was greater than the reduction in expression of human β-defensin-1. The aforementioned result suggests that the reduction in expression of human β-defensin-2 may occur earlier than the reduction in expression of human β-defensin-1, which may lead to a greater decrease in human β-defensin-2 than in human β-defensin-1 during disease progression.
KW - Defensin
KW - Minor salivary gland
KW - Sjögren's syndrome
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U2 - 10.1111/j.1600-0722.2009.00667.x
DO - 10.1111/j.1600-0722.2009.00667.x
M3 - Article
C2 - 19758245
AN - SCOPUS:70349202231
VL - 117
SP - 506
EP - 510
JO - European Journal of Oral Sciences
JF - European Journal of Oral Sciences
SN - 0909-8836
IS - 5
ER -