Localization of alpha-2 adrenergic receptors in the human eye

T. Matsuo, M. S. Cynader

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

To elucidate sites of the action of alpha-2 adrenergic drugs, we localized binding sites for a potent alpha-2 adrenergic agonist, UK-14,304, in sections of the human cadaveric eye by an in vitro ligand-binding technique and autoradiography. Its specific binding sites were found in the iris epithelium and ciliary epithelium at a high level, and also in the ciliary muscle, retina, retinal pigment epithelium (and/or choroid). Binding of UK-14,304 to the ocular pigments was prevented by preincubating the eye sections with chloroquine, which reduced the non-specific binding to a low level.

Original languageEnglish
Pages (from-to)213-219
Number of pages7
JournalOphthalmic Research
Volume24
Issue number4
DOIs
Publication statusPublished - Jan 1 1992

Keywords

  • Alpha-2 adrenergic receptor
  • Autoradiography
  • Human eye
  • Ligand-binding study
  • UK-14,304

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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