Localization and diffusion of tracer particles in viscoelastic media with active force dipoles

Kento Yasuda, Ryuichi Okamoto, Shigeyuki Komura, Alexander S. Mikhailov

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Optical tracking in vivo experiments reveal that diffusion of particles in biological cells is strongly enhanced in the presence of ATP and the experimental data for animal cells could previously be reproduced within a phenomenological model of a gel with myosin motors acting within it (Fodor É. et al., EPL, 110 (2015) 48005). Here, the two-fluid model of a gel is considered where active macromolecules, described as force dipoles, cyclically operate both in the elastic and the fluid components. Through coarse-graining, effective equations of motions for idealized tracer particles displaying local deformations and local fluid flows are derived. The equation for deformation tracers coincides with the earlier phenomenological model and thus confirms it. For flow tracers, diffusion enhancement caused by active force dipoles in the fluid component, and thus due to metabolic activity, is found. The latter effect may explain why ATP-dependent diffusion enhancement could also be observed in bacteria that lack molecular motors in their skeleton or when the activity of myosin motors was chemically inhibited in eukaryotic cells.

Original languageEnglish
Article number38001
JournalEPL
Volume117
Issue number3
DOIs
Publication statusPublished - Feb 1 2017
Externally publishedYes

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tracers
myosins
adenosine triphosphate
dipoles
gels
optical tracking
two fluid models
augmentation
fluids
cells
musculoskeletal system
macromolecules
bacteria
fluid flow
animals
equations of motion

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Localization and diffusion of tracer particles in viscoelastic media with active force dipoles. / Yasuda, Kento; Okamoto, Ryuichi; Komura, Shigeyuki; Mikhailov, Alexander S.

In: EPL, Vol. 117, No. 3, 38001, 01.02.2017.

Research output: Contribution to journalArticle

Yasuda, Kento ; Okamoto, Ryuichi ; Komura, Shigeyuki ; Mikhailov, Alexander S. / Localization and diffusion of tracer particles in viscoelastic media with active force dipoles. In: EPL. 2017 ; Vol. 117, No. 3.
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