TY - JOUR
T1 - Localisation of prostaglandin F(2α) and E2 binding sites in the human eye
AU - Matsuo, T.
AU - Cynader, M. S.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1992
Y1 - 1992
N2 - Prostaglandin F(2α) reduces intraocular pressure possibly by increasing uveoscleral outflow. To further understand the mechanism of its action binding sites for prostaglandin F(2α) and, for comparison, prostaglandin E2 were localised in sections of human cadaveric eyes using an in vitro ligand-binding technique and autoradiography. Specific binding sites for both prostaglandin F(2α) and E2 were co-localised at a high level in the areas of the ciliary muscles and iris sphincter muscles, and at a lower level in the iris epithelium and the retina. The results suggest that prostaglandin F(2α) and also prostaglandin E2, could modulate uveoscleral outflow by binding to their receptors located on the ciliary muscles and inducing their relaxation.
AB - Prostaglandin F(2α) reduces intraocular pressure possibly by increasing uveoscleral outflow. To further understand the mechanism of its action binding sites for prostaglandin F(2α) and, for comparison, prostaglandin E2 were localised in sections of human cadaveric eyes using an in vitro ligand-binding technique and autoradiography. Specific binding sites for both prostaglandin F(2α) and E2 were co-localised at a high level in the areas of the ciliary muscles and iris sphincter muscles, and at a lower level in the iris epithelium and the retina. The results suggest that prostaglandin F(2α) and also prostaglandin E2, could modulate uveoscleral outflow by binding to their receptors located on the ciliary muscles and inducing their relaxation.
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U2 - 10.1136/bjo.76.4.210
DO - 10.1136/bjo.76.4.210
M3 - Article
C2 - 1327095
AN - SCOPUS:0026611610
VL - 76
SP - 210
EP - 213
JO - British Journal of Ophthalmology
JF - British Journal of Ophthalmology
SN - 0007-1161
IS - 4
ER -