Localisation of prostaglandin F(2α) and E2 binding sites in the human eye

T. Matsuo, M. S. Cynader

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Prostaglandin F(2α) reduces intraocular pressure possibly by increasing uveoscleral outflow. To further understand the mechanism of its action binding sites for prostaglandin F(2α) and, for comparison, prostaglandin E2 were localised in sections of human cadaveric eyes using an in vitro ligand-binding technique and autoradiography. Specific binding sites for both prostaglandin F(2α) and E2 were co-localised at a high level in the areas of the ciliary muscles and iris sphincter muscles, and at a lower level in the iris epithelium and the retina. The results suggest that prostaglandin F(2α) and also prostaglandin E2, could modulate uveoscleral outflow by binding to their receptors located on the ciliary muscles and inducing their relaxation.

Original languageEnglish
Pages (from-to)210-213
Number of pages4
JournalBritish Journal of Ophthalmology
Volume76
Issue number4
DOIs
Publication statusPublished - Jan 1 1992

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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