Localisation of prostaglandin F(2α) and E2 binding sites in the human eye

Toshihiko Matsuo, M. S. Cynader

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Prostaglandin F(2α) reduces intraocular pressure possibly by increasing uveoscleral outflow. To further understand the mechanism of its action binding sites for prostaglandin F(2α) and, for comparison, prostaglandin E2 were localised in sections of human cadaveric eyes using an in vitro ligand-binding technique and autoradiography. Specific binding sites for both prostaglandin F(2α) and E2 were co-localised at a high level in the areas of the ciliary muscles and iris sphincter muscles, and at a lower level in the iris epithelium and the retina. The results suggest that prostaglandin F(2α) and also prostaglandin E2, could modulate uveoscleral outflow by binding to their receptors located on the ciliary muscles and inducing their relaxation.

Original languageEnglish
Pages (from-to)210-213
Number of pages4
JournalBritish Journal of Ophthalmology
Volume76
Issue number4
Publication statusPublished - 1992

Fingerprint

Prostaglandins F
Dinoprostone
Binding Sites
Iris
Muscles
Autoradiography
Intraocular Pressure
Retina
Epithelium
Ligands

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Localisation of prostaglandin F(2α) and E2 binding sites in the human eye. / Matsuo, Toshihiko; Cynader, M. S.

In: British Journal of Ophthalmology, Vol. 76, No. 4, 1992, p. 210-213.

Research output: Contribution to journalArticle

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