Living donor liver transplantation to a survivor of liver resection for hepatocellular carcinoma with major portal vein invasion

Hiroshi Sadamori, Takahito Yagi, Susumu Shinoura, Yuzo Umeda, Ryuichi Yoshida, Daisuke Sato, Daisuke Nobuoka, Masashi Utsumi, Toshiyoshi Fujiwara

Research output: Contribution to journalArticle

Abstract

We present a case of living donor liver transplantation to a 3-year disease-free survivor of liver resection for hepatocellular carcinoma (HCC) with major portal vein invasion A 48-year-old man had HCC in the right lobe with a portal venous tumor thrombus extending into the left portal vein. An extended right lobectomy with thrombectomy was performed to remove the thrombus. Three years after liver resection, the patient experienced liver failure, with massive ascites and jaundice due to the formation of a thrombus in the main and left portal veins. During the 3 years after liver resection, no metastasis or recurrence of HCC had been detected, and tumor markers had been within normal ranges. The portal venous thrombus did not show any arterial enhancement under contrast-enhanced computed tomography, suggesting that the co-existence of any HCC component in the portal venous thrombus may have been negative. Based on these findings, living donor liver transplantation was performed using a right lobe graft from the patient's son. The patient is alive at 87 months after the transplantation, with no evidence of HCC recurrence.

Original languageEnglish
Pages (from-to)117-121
Number of pages5
JournalActa medica Okayama
Volume67
Issue number2
Publication statusPublished - 2013

Keywords

  • Hepatocellular carcinoma
  • Liver resection
  • Living donor liver transplantation
  • Portal vein invasion

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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