Liver X receptor (LXR) modulators with dibenz[b,f]-[1,4]oxazepin-11-one, (Z)-dibenz[b,f]azocin-6-one, and 11,12-dihydrodibenz[b,f]azocin-6-one skeletons

Atsushi Aoyama, Hiroshi Aoyama, Makoto Makishima, Yuichi Hashimoto, Hiroyuki Miyachi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Conformationally restricted heterocyclic analogs of carba-T0901317 with dibenz[b,f][1,4]oxazepin-11-one, 11,12-dihydrodibenz[b,f)azocin-6-one, and (Z)-dibenz[b,f]-azocin-6-one skeletons were prepared as candidate for liver X receptor (LXR) agonists. In vitro transactivation assay revealed that the activity depends on the nature of the linking group.

Original languageEnglish
Pages (from-to)2209-2216
Number of pages8
JournalHeterocycles
Volume78
Issue number9
DOIs
Publication statusPublished - Sep 1 2009

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Keywords

  • (Z)-Dibenz[b,f]azocin-6-one
  • 11, 12-Dihydrodibenz[b,f]azocin-6-one
  • Dibenz[b,f][1,4]oxazepin-11-one
  • Liver X Receptor
  • LXR

ASJC Scopus subject areas

  • Analytical Chemistry
  • Organic Chemistry
  • Pharmacology

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