Conformationally restricted heterocyclic analogs of carba-T0901317 with dibenz[b,f][1,4]oxazepin-11-one, 11,12-dihydrodibenz[b,f)azocin-6-one, and (Z)-dibenz[b,f]-azocin-6-one skeletons were prepared as candidate for liver X receptor (LXR) agonists. In vitro transactivation assay revealed that the activity depends on the nature of the linking group.
- 11, 12-Dihydrodibenz[b,f]azocin-6-one
- Liver X Receptor
ASJC Scopus subject areas
- Analytical Chemistry
- Organic Chemistry