TY - JOUR
T1 - Liver X receptor (LXR) modulators with dibenz[b,f]-[1,4]oxazepin-11-one, (Z)-dibenz[b,f]azocin-6-one, and 11,12-dihydrodibenz[b,f]azocin-6-one skeletons
AU - Aoyama, Atsushi
AU - Aoyama, Hiroshi
AU - Makishima, Makoto
AU - Hashimoto, Yuichi
AU - Miyachi, Hiroyuki
PY - 2009/9/1
Y1 - 2009/9/1
N2 - Conformationally restricted heterocyclic analogs of carba-T0901317 with dibenz[b,f][1,4]oxazepin-11-one, 11,12-dihydrodibenz[b,f)azocin-6-one, and (Z)-dibenz[b,f]-azocin-6-one skeletons were prepared as candidate for liver X receptor (LXR) agonists. In vitro transactivation assay revealed that the activity depends on the nature of the linking group.
AB - Conformationally restricted heterocyclic analogs of carba-T0901317 with dibenz[b,f][1,4]oxazepin-11-one, 11,12-dihydrodibenz[b,f)azocin-6-one, and (Z)-dibenz[b,f]-azocin-6-one skeletons were prepared as candidate for liver X receptor (LXR) agonists. In vitro transactivation assay revealed that the activity depends on the nature of the linking group.
KW - (Z)-Dibenz[b,f]azocin-6-one
KW - 11, 12-Dihydrodibenz[b,f]azocin-6-one
KW - Dibenz[b,f][1,4]oxazepin-11-one
KW - LXR
KW - Liver X Receptor
UR - http://www.scopus.com/inward/record.url?scp=75849130010&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=75849130010&partnerID=8YFLogxK
U2 - 10.3987/COM-09-11738
DO - 10.3987/COM-09-11738
M3 - Article
AN - SCOPUS:75849130010
SN - 0385-5414
VL - 78
SP - 2209
EP - 2216
JO - Heterocycles
JF - Heterocycles
IS - 9
ER -