Liver X receptor antagonists with a phthalimide skeleton derived from thalidomide-related glucosidase inhibitors

Tomomi Noguchi-Yachide, Atsushi Aoyama, Makoto Makishima, Hiroyuki Miyachi, Yuichi Hashimoto

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

α-Glucosidase inhibitors with a chlorinated phthalimide or a thiophthalimide skeleton, derived from thalidomide, were found to possess liver X receptor (LXR) antagonistic activity. Novel LXR antagonists with a 2′-substituted phenylphthalimide skeleton were obtained by structural development of glucosidase inhibitors derived from thalidomide.

Original languageEnglish
Pages (from-to)3957-3961
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume17
Issue number14
DOIs
Publication statusPublished - Jul 15 2007
Externally publishedYes

Fingerprint

Glucosidases
Thalidomide
Skeleton
Liver
Liver X Receptors
phthalimide

Keywords

  • Antagonist
  • Glucosidase
  • Liver X receptor (LXR)
  • Phthalimide
  • Thalidomide

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Liver X receptor antagonists with a phthalimide skeleton derived from thalidomide-related glucosidase inhibitors. / Noguchi-Yachide, Tomomi; Aoyama, Atsushi; Makishima, Makoto; Miyachi, Hiroyuki; Hashimoto, Yuichi.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 17, No. 14, 15.07.2007, p. 3957-3961.

Research output: Contribution to journalArticle

Noguchi-Yachide, Tomomi ; Aoyama, Atsushi ; Makishima, Makoto ; Miyachi, Hiroyuki ; Hashimoto, Yuichi. / Liver X receptor antagonists with a phthalimide skeleton derived from thalidomide-related glucosidase inhibitors. In: Bioorganic and Medicinal Chemistry Letters. 2007 ; Vol. 17, No. 14. pp. 3957-3961.
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