Liver X receptor antagonists with a phthalimide skeleton derived from thalidomide-related glucosidase inhibitors

Tomomi Noguchi-Yachide, Atsushi Aoyama, Makoto Makishima, Hiroyuki Miyachi, Yuichi Hashimoto

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

α-Glucosidase inhibitors with a chlorinated phthalimide or a thiophthalimide skeleton, derived from thalidomide, were found to possess liver X receptor (LXR) antagonistic activity. Novel LXR antagonists with a 2′-substituted phenylphthalimide skeleton were obtained by structural development of glucosidase inhibitors derived from thalidomide.

Original languageEnglish
Pages (from-to)3957-3961
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume17
Issue number14
DOIs
Publication statusPublished - Jul 15 2007

Keywords

  • Antagonist
  • Glucosidase
  • Liver X receptor (LXR)
  • Phthalimide
  • Thalidomide

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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