Liver sarcoidosis with unique MRI images using gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid

Nozomu Wada, Kazuhiro Nouso, Kazuya Kariyama, Akiko Wakuta, Masayuki Kishida, Mamoru Nishimura, Toshihiro Higashi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Sarcoidosis is a systemic disease characterized by the formation of non-caseating granulomas in multiple organs. In the diagnosis of sarcoidosis, imaging modalities such as ultrasonography, computed tomography (CT) and magnetic resonance imaging (MRI) are useful; however, there are few reports of MRI imaging using gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB) MRI. A 46-year-old Japanese female with suspected pulmonary sarcoidosis was admitted to our hospital because low-density mottles in the liver were observed incidentally by chest CT. The low-density mottles were not enhanced at the arterial phase or portal phase by abdominal CT and MRI, and decreased uptake was observed in the hepatobiliary phase of Gd-EOB MRI. No hematological disorder was observed except for a slight increase of biliary enzymes. The lesion was diagnosed as liver sarcoidosis by the liver biopsy. Since the patient refused steroid therapy, we prescribed ursodeoxycholic acid (UDCA). 600mg/day. The serum levels of biliary enzymes were normalized and the abdominal CT findings gradually improved after the initiation of UDCA medication. Gd-EOB MRI showed unique hypointense areas in the liver at the hepatobiliary phase, which might be useful in the diagnosis of liver sarcoidosis.

Original languageEnglish
Pages (from-to)307-311
Number of pages5
JournalActa medica Okayama
Volume69
Issue number5
Publication statusPublished - 2015

Keywords

  • Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB)
  • Liver sarcoidosis
  • Ursodeoxycholic acid (UDCA)

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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