Abstract
A recently developed "GRAPE® technology" provides titanium or titanium alloy implants with spontaneous apatite-forming ability in vitro, which requires properly designed gaps and optimum heat treatment in air. In this study, titanium alloy and commercially pure (cp) titanium substrates were thermally oxidized in air before aligning pairs of specimens in the GRAPE® set-up, i.e., titanium alloy and cp titanium substrates were aligned parallel to each other with optimum gap width (spatial design). A liquid phase deposition (LPD) technique was employed for titania coatings on titanium alloy substrate. Then, they were soaked in Kokubo's simulated body fluid (SBF, pH 7.4, 36.5 C) for 7 days to confirm the in vitro apatite formation on the substrates under the specific spatial design. Anatase-type titania coatings fabricated by using LPD technique led to the deposition of apatite particles within 7 days and showed apatite X-ray diffraction. On the other hand, thermally oxidized titanium alloy substrate in air and non-treated specimens did not show any apatite X-ray diffraction. These results indicated that the heterogeneous nucleation of apatite induced on anatase-type titania coating prepared by LPD technique when it was aligned parallel to thermally oxidized cp titanium substrate with optimum gap width.
| Original language | English |
|---|---|
| Pages (from-to) | 375-381 |
| Number of pages | 7 |
| Journal | Journal of Materials Science: Materials in Medicine |
| Volume | 25 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2014 |
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ASJC Scopus subject areas
- Biophysics
- Biomaterials
- Bioengineering
- Biomedical Engineering
Cite this
Liquid phase deposited titania coating to enable in vitro apatite formation on Ti6Al4V alloy. / Hayakawa, Satoshi; Masuda, Yoshitake; Okamoto, Keigo; Shirosaki, Yuki; Kato, Kazumi; Osaka, Akiyoshi.
In: Journal of Materials Science: Materials in Medicine, Vol. 25, No. 2, 02.2014, p. 375-381.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Liquid phase deposited titania coating to enable in vitro apatite formation on Ti6Al4V alloy
AU - Hayakawa, Satoshi
AU - Masuda, Yoshitake
AU - Okamoto, Keigo
AU - Shirosaki, Yuki
AU - Kato, Kazumi
AU - Osaka, Akiyoshi
PY - 2014/2
Y1 - 2014/2
N2 - A recently developed "GRAPE® technology" provides titanium or titanium alloy implants with spontaneous apatite-forming ability in vitro, which requires properly designed gaps and optimum heat treatment in air. In this study, titanium alloy and commercially pure (cp) titanium substrates were thermally oxidized in air before aligning pairs of specimens in the GRAPE® set-up, i.e., titanium alloy and cp titanium substrates were aligned parallel to each other with optimum gap width (spatial design). A liquid phase deposition (LPD) technique was employed for titania coatings on titanium alloy substrate. Then, they were soaked in Kokubo's simulated body fluid (SBF, pH 7.4, 36.5 C) for 7 days to confirm the in vitro apatite formation on the substrates under the specific spatial design. Anatase-type titania coatings fabricated by using LPD technique led to the deposition of apatite particles within 7 days and showed apatite X-ray diffraction. On the other hand, thermally oxidized titanium alloy substrate in air and non-treated specimens did not show any apatite X-ray diffraction. These results indicated that the heterogeneous nucleation of apatite induced on anatase-type titania coating prepared by LPD technique when it was aligned parallel to thermally oxidized cp titanium substrate with optimum gap width.
AB - A recently developed "GRAPE® technology" provides titanium or titanium alloy implants with spontaneous apatite-forming ability in vitro, which requires properly designed gaps and optimum heat treatment in air. In this study, titanium alloy and commercially pure (cp) titanium substrates were thermally oxidized in air before aligning pairs of specimens in the GRAPE® set-up, i.e., titanium alloy and cp titanium substrates were aligned parallel to each other with optimum gap width (spatial design). A liquid phase deposition (LPD) technique was employed for titania coatings on titanium alloy substrate. Then, they were soaked in Kokubo's simulated body fluid (SBF, pH 7.4, 36.5 C) for 7 days to confirm the in vitro apatite formation on the substrates under the specific spatial design. Anatase-type titania coatings fabricated by using LPD technique led to the deposition of apatite particles within 7 days and showed apatite X-ray diffraction. On the other hand, thermally oxidized titanium alloy substrate in air and non-treated specimens did not show any apatite X-ray diffraction. These results indicated that the heterogeneous nucleation of apatite induced on anatase-type titania coating prepared by LPD technique when it was aligned parallel to thermally oxidized cp titanium substrate with optimum gap width.
UR - http://www.scopus.com/inward/record.url?scp=84894417086&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84894417086&partnerID=8YFLogxK
U2 - 10.1007/s10856-013-5078-z
DO - 10.1007/s10856-013-5078-z
M3 - Article
C2 - 24165799
AN - SCOPUS:84894417086
VL - 25
SP - 375
EP - 381
JO - Journal of Materials Science: Materials in Medicine
JF - Journal of Materials Science: Materials in Medicine
SN - 0957-4530
IS - 2
ER -