Lipoprotein particle profiles compared with standard lipids in the association with subclinical aortic valve calcification in apparently healthy Japanese men

for the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) Research Group

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Risk factors for atherosclerotic disease including dyslipidemia have been shown to be associated with aortic valve calcification (AVC). Nuclear magnetic resonance (NMR)-measured lipoprotein particles, low-density and high-density lipoprotein particles (LDL-p, HDL-p) in particular, have emerged as novel markers of atherosclerotic disease; however, whether NMR-measured particles are associated with AVC remains to be determined. This study aimed to examine the association between NMR-based lipoprotein particle measurements and standard lipids with AVC. The primary variables of interest were LDL-p (nmol/L), HDL-p (μmol/L), LDL-cholesterol, and HDL-cholesterol (both in mg/dL). Methods and Results: A community-based random sample of Japanese men aged 40–79 years examined in 2006–2008, in Shiga, Japan was studied. Presence of AVC was defined as an Agatston score >0. Lipoprotein particles were measured using NMR spectroscopy. In the main analysis, multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) for the prevalence of AVC across the higher quartiles of lipids in reference to the lowest ones were obtained. Of 874 participants analyzed, 153 men had AVC. Multivariable-adjusted ORs of prevalent AVC for the highest vs. the lowest quartile were significantly elevated for LDL-p (OR, 2.20; 95% CI: 1.23–3.93) and LDL-cholesterol (OR, 2.16; 95% CI: 1.23–3.78). In contrast, neither HDL-p nor HDL-cholesterol was associated with AVC. Conclusions: The association of prevalent AVC with NMR-based LDL-p was comparable to that with LDL-cholesterol.

Original languageEnglish
Pages (from-to)1076-1082
Number of pages7
JournalCirculation Journal
Volume85
Issue number7
DOIs
Publication statusPublished - 2021

Keywords

  • Aortic valve calcification (AVC)
  • High-density lipoprotein particles (HDL-p)
  • Low-density lipoprotein particles (LDL-p)

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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