Lipo-microdialysis

A new microdialysis method for studying the pharmacokinetics of lipophilic substances

Yuji Kurosaki, Shinya Nakamura, Yoko Shiojiri, Hiromu Kawasaki

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

A new microdialysis method (Lipo-MD) using a lipid emulsion as the perfusate instead of Ringer's solution as in conventional microdialysis (MD) was designed. Recovery profiles of the alkylparabens (APBs) dissolved in Ringer's solution by Lipo-MD were compared with those by ME) in vitro. Recovery of APBs in the perfusate in MD decreased with the increasing lipophilicity of APBs, whereas that in Lipo-MD increased. The enhancement of the relative recovery of APBs by Lipo-MD to MD for methyl-, ethyl-, propyl-, and butylparaben were 2.03, 5.24, 77.0, and 390.7, respectively. The utility of Lipo-MD for determination of lipophilic substances to perform pharmacokinetic study was suggested.

Original languageEnglish
Pages (from-to)194-196
Number of pages3
JournalBiological and Pharmaceutical Bulletin
Volume21
Issue number2
Publication statusPublished - 1998

Fingerprint

Microdialysis
Pharmacokinetics
Emulsions
Lipids

Keywords

  • Alkylparaben
  • Lipid emulsion
  • Lipo-microdialysis
  • Lipophilic substance
  • Microdialysis
  • Pharmacokinetics

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Lipo-microdialysis : A new microdialysis method for studying the pharmacokinetics of lipophilic substances. / Kurosaki, Yuji; Nakamura, Shinya; Shiojiri, Yoko; Kawasaki, Hiromu.

In: Biological and Pharmaceutical Bulletin, Vol. 21, No. 2, 1998, p. 194-196.

Research output: Contribution to journalArticle

@article{76ab708ec7cc4b18bfeb08c6c0c3754f,
title = "Lipo-microdialysis: A new microdialysis method for studying the pharmacokinetics of lipophilic substances",
abstract = "A new microdialysis method (Lipo-MD) using a lipid emulsion as the perfusate instead of Ringer's solution as in conventional microdialysis (MD) was designed. Recovery profiles of the alkylparabens (APBs) dissolved in Ringer's solution by Lipo-MD were compared with those by ME) in vitro. Recovery of APBs in the perfusate in MD decreased with the increasing lipophilicity of APBs, whereas that in Lipo-MD increased. The enhancement of the relative recovery of APBs by Lipo-MD to MD for methyl-, ethyl-, propyl-, and butylparaben were 2.03, 5.24, 77.0, and 390.7, respectively. The utility of Lipo-MD for determination of lipophilic substances to perform pharmacokinetic study was suggested.",
keywords = "Alkylparaben, Lipid emulsion, Lipo-microdialysis, Lipophilic substance, Microdialysis, Pharmacokinetics",
author = "Yuji Kurosaki and Shinya Nakamura and Yoko Shiojiri and Hiromu Kawasaki",
year = "1998",
language = "English",
volume = "21",
pages = "194--196",
journal = "Biological and Pharmaceutical Bulletin",
issn = "0918-6158",
publisher = "Pharmaceutical Society of Japan",
number = "2",

}

TY - JOUR

T1 - Lipo-microdialysis

T2 - A new microdialysis method for studying the pharmacokinetics of lipophilic substances

AU - Kurosaki, Yuji

AU - Nakamura, Shinya

AU - Shiojiri, Yoko

AU - Kawasaki, Hiromu

PY - 1998

Y1 - 1998

N2 - A new microdialysis method (Lipo-MD) using a lipid emulsion as the perfusate instead of Ringer's solution as in conventional microdialysis (MD) was designed. Recovery profiles of the alkylparabens (APBs) dissolved in Ringer's solution by Lipo-MD were compared with those by ME) in vitro. Recovery of APBs in the perfusate in MD decreased with the increasing lipophilicity of APBs, whereas that in Lipo-MD increased. The enhancement of the relative recovery of APBs by Lipo-MD to MD for methyl-, ethyl-, propyl-, and butylparaben were 2.03, 5.24, 77.0, and 390.7, respectively. The utility of Lipo-MD for determination of lipophilic substances to perform pharmacokinetic study was suggested.

AB - A new microdialysis method (Lipo-MD) using a lipid emulsion as the perfusate instead of Ringer's solution as in conventional microdialysis (MD) was designed. Recovery profiles of the alkylparabens (APBs) dissolved in Ringer's solution by Lipo-MD were compared with those by ME) in vitro. Recovery of APBs in the perfusate in MD decreased with the increasing lipophilicity of APBs, whereas that in Lipo-MD increased. The enhancement of the relative recovery of APBs by Lipo-MD to MD for methyl-, ethyl-, propyl-, and butylparaben were 2.03, 5.24, 77.0, and 390.7, respectively. The utility of Lipo-MD for determination of lipophilic substances to perform pharmacokinetic study was suggested.

KW - Alkylparaben

KW - Lipid emulsion

KW - Lipo-microdialysis

KW - Lipophilic substance

KW - Microdialysis

KW - Pharmacokinetics

UR - http://www.scopus.com/inward/record.url?scp=0031886381&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031886381&partnerID=8YFLogxK

M3 - Article

VL - 21

SP - 194

EP - 196

JO - Biological and Pharmaceutical Bulletin

JF - Biological and Pharmaceutical Bulletin

SN - 0918-6158

IS - 2

ER -