Lipo-microdialysis: A new microdialysis method for studying the pharmacokinetics of lipophilic substances

Yuji Kurosaki, Shinya Nakamura, Yoko Shiojiri, Hiromu Kawasaki

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

A new microdialysis method (Lipo-MD) using a lipid emulsion as the perfusate instead of Ringer's solution as in conventional microdialysis (MD) was designed. Recovery profiles of the alkylparabens (APBs) dissolved in Ringer's solution by Lipo-MD were compared with those by ME) in vitro. Recovery of APBs in the perfusate in MD decreased with the increasing lipophilicity of APBs, whereas that in Lipo-MD increased. The enhancement of the relative recovery of APBs by Lipo-MD to MD for methyl-, ethyl-, propyl-, and butylparaben were 2.03, 5.24, 77.0, and 390.7, respectively. The utility of Lipo-MD for determination of lipophilic substances to perform pharmacokinetic study was suggested.

Original languageEnglish
Pages (from-to)194-196
Number of pages3
JournalBiological and Pharmaceutical Bulletin
Volume21
Issue number2
DOIs
Publication statusPublished - Jan 1 1998

Keywords

  • Alkylparaben
  • Lipid emulsion
  • Lipo-microdialysis
  • Lipophilic substance
  • Microdialysis
  • Pharmacokinetics

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

Fingerprint Dive into the research topics of 'Lipo-microdialysis: A new microdialysis method for studying the pharmacokinetics of lipophilic substances'. Together they form a unique fingerprint.

  • Cite this