Lipase-catalyzed kinetic resolution of large secondary alcohols having tetraphenylporphyrin

Tadashi Ema, Masahito Jittani, Takashi Sakai, Masanori Utaka

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


Large secondary alcohols, 5-[4-(1-hydroxyethyl)phenyl]-10,15,20- triphenylporphyrin (1a) and the zinc complex 1b, designed on the basis of the transition-state model recently proposed by us, were subjected to the lipase- catalyzed transesterifications. The alcohols were resolved using lipases from Pseudomonas cepacia (lipase PS), Candida antarctica (CHIRAZYME L-2), Rhizomucor miehei (CHIRAZYME L-9), and Pseudomonas aeruginosa (lipase LIP) with high enantioselectivities (E > 100).

Original languageEnglish
Pages (from-to)6311-6314
Number of pages4
JournalTetrahedron Letters
Issue number35
Publication statusPublished - Aug 27 1998

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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