TY - JOUR
T1 - Lipase-catalyzed kinetic resolution of large secondary alcohols having tetraphenylporphyrin
AU - Ema, Tadashi
AU - Jittani, Masahito
AU - Sakai, Takashi
AU - Utaka, Masanori
PY - 1998/8/27
Y1 - 1998/8/27
N2 - Large secondary alcohols, 5-[4-(1-hydroxyethyl)phenyl]-10,15,20- triphenylporphyrin (1a) and the zinc complex 1b, designed on the basis of the transition-state model recently proposed by us, were subjected to the lipase- catalyzed transesterifications. The alcohols were resolved using lipases from Pseudomonas cepacia (lipase PS), Candida antarctica (CHIRAZYME L-2), Rhizomucor miehei (CHIRAZYME L-9), and Pseudomonas aeruginosa (lipase LIP) with high enantioselectivities (E > 100).
AB - Large secondary alcohols, 5-[4-(1-hydroxyethyl)phenyl]-10,15,20- triphenylporphyrin (1a) and the zinc complex 1b, designed on the basis of the transition-state model recently proposed by us, were subjected to the lipase- catalyzed transesterifications. The alcohols were resolved using lipases from Pseudomonas cepacia (lipase PS), Candida antarctica (CHIRAZYME L-2), Rhizomucor miehei (CHIRAZYME L-9), and Pseudomonas aeruginosa (lipase LIP) with high enantioselectivities (E > 100).
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U2 - 10.1016/S0040-4039(98)01338-0
DO - 10.1016/S0040-4039(98)01338-0
M3 - Article
AN - SCOPUS:0032572886
SN - 0040-4039
VL - 39
SP - 6311
EP - 6314
JO - Tetrahedron Letters
JF - Tetrahedron Letters
IS - 35
ER -