Abstract
The lipase-catalyzed kinetic resolution of (±)-2-acyloxy-2- (pentafluorophenyl)acetonitrile (±)-1 gave optically active cyanohydrin (S)- 2 and its antipodal ester (R)-1 (E = 211), the former of which was transformed (TBSOTf, DMAP) into its TBS-ether (S)-3, a new fluorinated chiral building block, and into naproxen ester 4 for X-ray analysis to determine the absolute configuration.
Original language | English |
---|---|
Pages (from-to) | 5233-5236 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 39 |
Issue number | 29 |
DOIs | |
Publication status | Published - Jul 16 1998 |
Keywords
- Cyanohydrins
- Enzymes and enzyme reactions
- Resolution
- X-ray crystal structures
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry