@article{a2b4404b1bbf4b00a45dd6964624fff6,
title = "Lipase-catalyzed kinetic resolution of 2-acyloxy-2- (pentafluorophenyl)acetonitrile",
abstract = "The lipase-catalyzed kinetic resolution of (±)-2-acyloxy-2- (pentafluorophenyl)acetonitrile (±)-1 gave optically active cyanohydrin (S)- 2 and its antipodal ester (R)-1 (E = 211), the former of which was transformed (TBSOTf, DMAP) into its TBS-ether (S)-3, a new fluorinated chiral building block, and into naproxen ester 4 for X-ray analysis to determine the absolute configuration.",
keywords = "Cyanohydrins, Enzymes and enzyme reactions, Resolution, X-ray crystal structures",
author = "Takashi Sakai and Yasushi Miki and Mayumi Nakatani and Tadashi Ema and Kenji Uneyama and Masanori Utaka",
note = "Funding Information: This work was partially supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan. We are grateful to Amano Pharmaceutical Co., Ltd., Toyobo Co., Ltd. and Sumitomo Chemical Co., Ltd. for kind supply of the lipases. We also thank the SC-NMR laboratory for ~gF NMR (188 MHz) and ~H NMR (500 and 200 MHz) analyses, and the Veature Business Laboratory of Okayama University for X-ray analysis. Copyright: Copyright 2007 Elsevier B.V., All rights reserved.",
year = "1998",
month = jul,
day = "16",
doi = "10.1016/S0040-4039(98)01029-6",
language = "English",
volume = "39",
pages = "5233--5236",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "29",
}