Linkage of expression of chemokine receptors (CXCR3 and CCR4) and cytotoxic molecules in peripheral T cell lymphoma, not otherwise specified and ALK-negative anaplastic large cell lymphoma

Naoko Asano, Ritsuro Suzuki, Koichi Ohshima, Yoshitoyo Kagami, Fumihiro Ishida, Tadashi Yoshino, Hiroshi Ogawa, Yasuo Morishima, Shigeo Nakamura

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Peripheral T cell lymphoma not otherwise specified (PTCL-N) and ALK-negative anaplastic large cell lymphoma (ALCL) are heterogeneous categories with poor diagnostic reproducibility. To clarify the biologic features of these categories, we investigated the expression of two chemokine receptors, type 1 (Th1/Tc1)-associated CXCR3 and type 2 (Th2/Tc2)-associated CCR4 in 110 PTCL-N and 35 ALK-negative ALCL cases, as well as the expression of cytotoxic molecules (CM). CXCR3 and CCR4 were expressed in 69 (63%) and 37 (34%) of PTCL-N, and in 12 (34%) and 6 (17%) of ALK-negative ALCL, respectively. In PTCL-N, type 1 pattern (CXCR3+CCR4-) was dominant (52%), whereas in ALK-negative ALCL, 54% were negative for both (P <0.0001). CM was expressed in 38% of PTCL-N and 51% of ALK-negative ALCL. CM-positive PTCL-N consisted mostly of type 1 disease, which shows type 1 phenotype. In contrast, type 2 pattern (CXCR3-CCR4+) was recognized in the CM-negative group only. Among type 1 disease, CM-positive cases had a higher female ratio and more aggressive clinical features than CM-negative cases and a poorer prognosis (P = 0.006). Multivariate analysis confirmed that the type 1 phenotype with CM expression was an independent prognostic factor. In both PTCL-N and ALK-negative ALCL, CM-positive type 1 disease had an extremely poor prognosis.

Original languageEnglish
Pages (from-to)426-435
Number of pages10
JournalInternational Journal of Hematology
Volume91
Issue number3
DOIs
Publication statusPublished - Apr 2010

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Peripheral T-Cell Lymphoma
Anaplastic Large-Cell Lymphoma
Chemokine Receptors
Phenotype
Multivariate Analysis

Keywords

  • ALK-negative anaplastic large cell lymphoma (ALCL)
  • Chemokine receptor
  • Cytotoxic molecule
  • Peripheral T cell lymphoma, not otherwise specified (PTCL-N)
  • Prognosis

ASJC Scopus subject areas

  • Hematology

Cite this

Linkage of expression of chemokine receptors (CXCR3 and CCR4) and cytotoxic molecules in peripheral T cell lymphoma, not otherwise specified and ALK-negative anaplastic large cell lymphoma. / Asano, Naoko; Suzuki, Ritsuro; Ohshima, Koichi; Kagami, Yoshitoyo; Ishida, Fumihiro; Yoshino, Tadashi; Ogawa, Hiroshi; Morishima, Yasuo; Nakamura, Shigeo.

In: International Journal of Hematology, Vol. 91, No. 3, 04.2010, p. 426-435.

Research output: Contribution to journalArticle

Asano, Naoko ; Suzuki, Ritsuro ; Ohshima, Koichi ; Kagami, Yoshitoyo ; Ishida, Fumihiro ; Yoshino, Tadashi ; Ogawa, Hiroshi ; Morishima, Yasuo ; Nakamura, Shigeo. / Linkage of expression of chemokine receptors (CXCR3 and CCR4) and cytotoxic molecules in peripheral T cell lymphoma, not otherwise specified and ALK-negative anaplastic large cell lymphoma. In: International Journal of Hematology. 2010 ; Vol. 91, No. 3. pp. 426-435.
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abstract = "Peripheral T cell lymphoma not otherwise specified (PTCL-N) and ALK-negative anaplastic large cell lymphoma (ALCL) are heterogeneous categories with poor diagnostic reproducibility. To clarify the biologic features of these categories, we investigated the expression of two chemokine receptors, type 1 (Th1/Tc1)-associated CXCR3 and type 2 (Th2/Tc2)-associated CCR4 in 110 PTCL-N and 35 ALK-negative ALCL cases, as well as the expression of cytotoxic molecules (CM). CXCR3 and CCR4 were expressed in 69 (63{\%}) and 37 (34{\%}) of PTCL-N, and in 12 (34{\%}) and 6 (17{\%}) of ALK-negative ALCL, respectively. In PTCL-N, type 1 pattern (CXCR3+CCR4-) was dominant (52{\%}), whereas in ALK-negative ALCL, 54{\%} were negative for both (P <0.0001). CM was expressed in 38{\%} of PTCL-N and 51{\%} of ALK-negative ALCL. CM-positive PTCL-N consisted mostly of type 1 disease, which shows type 1 phenotype. In contrast, type 2 pattern (CXCR3-CCR4+) was recognized in the CM-negative group only. Among type 1 disease, CM-positive cases had a higher female ratio and more aggressive clinical features than CM-negative cases and a poorer prognosis (P = 0.006). Multivariate analysis confirmed that the type 1 phenotype with CM expression was an independent prognostic factor. In both PTCL-N and ALK-negative ALCL, CM-positive type 1 disease had an extremely poor prognosis.",
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AU - Asano, Naoko

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AU - Ohshima, Koichi

AU - Kagami, Yoshitoyo

AU - Ishida, Fumihiro

AU - Yoshino, Tadashi

AU - Ogawa, Hiroshi

AU - Morishima, Yasuo

AU - Nakamura, Shigeo

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AB - Peripheral T cell lymphoma not otherwise specified (PTCL-N) and ALK-negative anaplastic large cell lymphoma (ALCL) are heterogeneous categories with poor diagnostic reproducibility. To clarify the biologic features of these categories, we investigated the expression of two chemokine receptors, type 1 (Th1/Tc1)-associated CXCR3 and type 2 (Th2/Tc2)-associated CCR4 in 110 PTCL-N and 35 ALK-negative ALCL cases, as well as the expression of cytotoxic molecules (CM). CXCR3 and CCR4 were expressed in 69 (63%) and 37 (34%) of PTCL-N, and in 12 (34%) and 6 (17%) of ALK-negative ALCL, respectively. In PTCL-N, type 1 pattern (CXCR3+CCR4-) was dominant (52%), whereas in ALK-negative ALCL, 54% were negative for both (P <0.0001). CM was expressed in 38% of PTCL-N and 51% of ALK-negative ALCL. CM-positive PTCL-N consisted mostly of type 1 disease, which shows type 1 phenotype. In contrast, type 2 pattern (CXCR3-CCR4+) was recognized in the CM-negative group only. Among type 1 disease, CM-positive cases had a higher female ratio and more aggressive clinical features than CM-negative cases and a poorer prognosis (P = 0.006). Multivariate analysis confirmed that the type 1 phenotype with CM expression was an independent prognostic factor. In both PTCL-N and ALK-negative ALCL, CM-positive type 1 disease had an extremely poor prognosis.

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KW - Peripheral T cell lymphoma, not otherwise specified (PTCL-N)

KW - Prognosis

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