Linkage mapping of the locus responsible for forelimb-girdle muscular anomaly of Japanese black cattle on bovine chromosome 26

A. A. Masoudi, K. Uchida, K. Yokouchi, K. Ohwada, A. R. Abbasi, Takehito Tsuji, T. Watanabe, T. Hirano, Y. Sugimoto, Tetsuo Kunieda

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Forelimb-girdle muscular anomaly is an autosomal recessive disorder of Japanese black cattle characterized by tremor, astasia and abnormal shape of the shoulders. Pathological examination of affected animals reveals hypoplasia of forelimb-girdle muscles with reduced diameter of muscle fibres. To identify the gene responsible for this disorder, we performed linkage mapping of the disorder locus using an inbred pedigree including a great-grand sire, a grand sire, a sire and 26 affected calves obtained from a herd of Japanese black cattle. Two hundred and fifty-eight microsatellite markers distributed across the genome were genotyped across the pedigree. Four markers on the middle region of bovine chromosome 26 showed significant linkage with the disorder locus. Haplotype analysis using additional markers in this region refined the critical region of the disorder locus to a 3.5-Mb interval on BTA26 between BM4505 and MOK2602. Comparative mapping data revealed several potential candidate genes for the disorder, including NRAP, PDZD8 and HSPA12A, which are associated with muscular function.

Original languageEnglish
Pages (from-to)46-50
Number of pages5
JournalAnimal Genetics
Volume39
Issue number1
DOIs
Publication statusPublished - Feb 2008

Fingerprint

Wagyu
Forelimb
Chromosome Mapping
forelimbs
sires
chromosome mapping
Chromosomes
Pedigree
chromosomes
pedigree
loci
cattle
Astasia
Muscles
Tremor
shoulders
muscle fibers
Microsatellite Repeats
Haplotypes
Genes

Keywords

  • Hereditary disorder
  • Japanese black cattle
  • Mapping
  • Muscular anomaly

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Genetics
  • Genetics(clinical)

Cite this

Linkage mapping of the locus responsible for forelimb-girdle muscular anomaly of Japanese black cattle on bovine chromosome 26. / Masoudi, A. A.; Uchida, K.; Yokouchi, K.; Ohwada, K.; Abbasi, A. R.; Tsuji, Takehito; Watanabe, T.; Hirano, T.; Sugimoto, Y.; Kunieda, Tetsuo.

In: Animal Genetics, Vol. 39, No. 1, 02.2008, p. 46-50.

Research output: Contribution to journalArticle

Masoudi, A. A. ; Uchida, K. ; Yokouchi, K. ; Ohwada, K. ; Abbasi, A. R. ; Tsuji, Takehito ; Watanabe, T. ; Hirano, T. ; Sugimoto, Y. ; Kunieda, Tetsuo. / Linkage mapping of the locus responsible for forelimb-girdle muscular anomaly of Japanese black cattle on bovine chromosome 26. In: Animal Genetics. 2008 ; Vol. 39, No. 1. pp. 46-50.
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