Limb regeneration

Reconstitution of complex organs using specific tissue interactions

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Limb regeneration in amphibians has been investigated for a long time because we still have not found a way to regenerate our body parts. Urodele amphibians generally have the ability to regenerate most of their organs. Limb regeneration has been investigated as a representative phenomenon of their high regeneration ability. Limb amputation in urodele amphibians causes regeneration blastema formation. A regeneration blastema is composed of undifferentiated cells called blastema cells. This blastema induction mechanism is the issue that has been the focus of study for a long time. Nerve tissue is known to be key for successful blastema formation and limb regeneration. Despite the importance of the nerve tissue in limb regeneration, its molecular description is not well established. Recently, a brand-new experimental system called an accessory limb model (ALM) was reported that is designed to reveal minimum and necessary tissue interaction including nerves. In this chapter, necessary tissue interactions for blastema induction in the ALM and related molecular descriptions are given.

Original languageEnglish
Title of host publicationNew Principles in Developmental Processes
PublisherSpringer Japan
Pages197-210
Number of pages14
Volume9784431546344
ISBN (Print)9784431546344, 4431546332, 9784431546337
DOIs
Publication statusPublished - Nov 1 2014

Fingerprint

Regeneration
Extremities
Tissue
Accessories
Amphibians
Nerve Tissue
Molecular Models
Amputation
Human Body

Keywords

  • Accessory limb model (ALM)
  • Apical epithelial/epithelium cap (AEC)
  • Blastema
  • Dedifferentiation
  • Limb regeneration
  • Nerve factor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Sato, A. (2014). Limb regeneration: Reconstitution of complex organs using specific tissue interactions. In New Principles in Developmental Processes (Vol. 9784431546344, pp. 197-210). Springer Japan. https://doi.org/10.1007/978-4-431-54634-4_15

Limb regeneration : Reconstitution of complex organs using specific tissue interactions. / Sato, Akira.

New Principles in Developmental Processes. Vol. 9784431546344 Springer Japan, 2014. p. 197-210.

Research output: Chapter in Book/Report/Conference proceedingChapter

Sato, A 2014, Limb regeneration: Reconstitution of complex organs using specific tissue interactions. in New Principles in Developmental Processes. vol. 9784431546344, Springer Japan, pp. 197-210. https://doi.org/10.1007/978-4-431-54634-4_15
Sato A. Limb regeneration: Reconstitution of complex organs using specific tissue interactions. In New Principles in Developmental Processes. Vol. 9784431546344. Springer Japan. 2014. p. 197-210 https://doi.org/10.1007/978-4-431-54634-4_15
Sato, Akira. / Limb regeneration : Reconstitution of complex organs using specific tissue interactions. New Principles in Developmental Processes. Vol. 9784431546344 Springer Japan, 2014. pp. 197-210
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