Light chain deposition disease involving kidney and liver in a patient with IgD myeloma

Takafumi Tsushima, Tomo Suzuki, Toshiki Terao, Daisuke Miura, Kentaro Narita, Masami Takeuchi, Akira Shimuzu, Kosei Matsue

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Background: IgD multiple myeloma (MM) is a rare subtype of MM and light chain deposition disease (LCDD) outside the kidney is also a rare and has scarcely been reported. We report herein the details of the first reported case of LCDD involving the kidney and liver co-occurring with IgD myeloma. Case presentation: A 66-year-old female with IgD MM presented with rapidly progressive acute renal failure, ascites and pleural effusion. Immunofluorescent study of revealed the characteristic linear deposition of Igκ light chain along the glomerular and tubular basement membrane in kidney. Electron microscopy showed the powdery electron-dense deposits along the tubular and glomerular basement membrane consistent with the diagnosis of LCDD. Laser microdissection followed by mass spectrometry identified only Igκ light chain with more than 95% probability confirm the diagnosis of κ-LCDD but not heavy/light chain deposition disease. Liver biopsy with immunofluorescence study revealed the linear deposition of Igκ chain along the perisinusoidal space indicating the hepatic involvement of κ-LCDD. The patient was successfully treated with combination therapy with bortezomib, cyclophosphamide, dexamethasone, and daratumumab. Conclusions: This report emphasizes that prompt biopsy of affected organs and initiation of clone directed therapy led to the correct diagnosis and favorable outcome in patient with LCDD who has extrarenal involvement.

Original languageEnglish
Article number40
JournalBMC nephrology
Issue number1
Publication statusPublished - Dec 2021
Externally publishedYes


  • CyBorD
  • Daratumumab
  • IgD myeloma
  • Light chain deposition disease
  • Liver involvement

ASJC Scopus subject areas

  • Nephrology


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