Ligands with dual vitamin D3-agonistic and androgen-antagonistic activities

Shinnosuke Hosoda, Aya Tanatani, Ken Ichi Wakabayashi, Yusuke Nakano, Hiroyuki Miyachi, Kazuo Nagasawa, Yuichi Hashimoto

Research output: Contribution to journalArticle

39 Citations (Scopus)


Ligands possessing dual vitamin D3-agonistic (estimated as HL-60 monocytic cell differentiation induction) and androgen-antagonistic (estimated as testosterone-induced SC-3 cell growth inhibition) activities with various activity spectra were prepared based on a substituted bis-phenylmethane skeleton. Some of them were revealed to be potent androgen antagonists with a nonsecosteroidal vitamin D3 skeleton.

Original languageEnglish
Pages (from-to)4327-4331
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Issue number19
Publication statusPublished - Oct 1 2005
Externally publishedYes



  • Androgen antagonist
  • Bisphenylmethane
  • Vitamin D

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Hosoda, S., Tanatani, A., Wakabayashi, K. I., Nakano, Y., Miyachi, H., Nagasawa, K., & Hashimoto, Y. (2005). Ligands with dual vitamin D3-agonistic and androgen-antagonistic activities. Bioorganic and Medicinal Chemistry Letters, 15(19), 4327-4331.