Lidocaine protects hippocampal neurons against ischemic damage by preventing increase of extracellular excitatory amino acids: a microdialysis study in Mongolian gerbils

Taro Fujitani, Naoto Adachi, Hirofumi Miyazaki, Keyue Liu, Yoichi Nakamura, Kiyoshi Kataoka, Tatsuru Arai

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Extracellular levels of amino acids in the hippocampal CA1 region of the gerbil were analyzed by a microdialysis-HPLC procedure. Transient forebrain ischemia produced significant increase in aspartate, glutamate, glycine and taurine (760%, 1070%, 190% and 1210%, respectively), and neuronal blockade by perfusion with a lidocaine (4 mM)-containing medium resulted in 67%, 79%, 58% and 59% reduction in the peak values of each amino acid, respectively. On the other hand, an intracerebroventricular administration of lidocaine, 0.8 μmol or more, produced a protective effect against delayed damage of hippocampal CA1 pyramidal cells, which was caused by bilateral carotid artery occlusion for 4 min. The results suggest that lidocaine may protect neurons against ischemic damage, by preventing the ischemia-induced rise of extracellular concentration of excitatory amino acid.

Original languageEnglish
Pages (from-to)91-94
Number of pages4
JournalNeuroscience Letters
Volume179
Issue number1-2
DOIs
Publication statusPublished - Sep 26 1994
Externally publishedYes

Fingerprint

Excitatory Amino Acids
Gerbillinae
Microdialysis
Lidocaine
Neurons
Ischemia
Hippocampal CA1 Region
Amino Acids
Pyramidal Cells
Taurine
Prosencephalon
Carotid Arteries
Aspartic Acid
Glycine
Glutamic Acid
Perfusion
High Pressure Liquid Chromatography

Keywords

  • Amino acids
  • CA1
  • Cerebral ischemia
  • Hippocampus
  • Lidocaine
  • Microdialysis
  • Mongolian gerbils

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Lidocaine protects hippocampal neurons against ischemic damage by preventing increase of extracellular excitatory amino acids : a microdialysis study in Mongolian gerbils. / Fujitani, Taro; Adachi, Naoto; Miyazaki, Hirofumi; Liu, Keyue; Nakamura, Yoichi; Kataoka, Kiyoshi; Arai, Tatsuru.

In: Neuroscience Letters, Vol. 179, No. 1-2, 26.09.1994, p. 91-94.

Research output: Contribution to journalArticle

Fujitani, Taro ; Adachi, Naoto ; Miyazaki, Hirofumi ; Liu, Keyue ; Nakamura, Yoichi ; Kataoka, Kiyoshi ; Arai, Tatsuru. / Lidocaine protects hippocampal neurons against ischemic damage by preventing increase of extracellular excitatory amino acids : a microdialysis study in Mongolian gerbils. In: Neuroscience Letters. 1994 ; Vol. 179, No. 1-2. pp. 91-94.
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