Levels of annexin IV and V in the plasma of pregnant and postpartum women

Junko Masuda, Eiji Takayama, Ayano Satoh, Michiru Ida, Tadashi Shinohara, Kyoko Kojima-Aikawa, Fumitaka Ohsuzu, Kuniaki Nakanishi, Koichi Kuroda, Mitsutaka Murakami, Kimihiro Suzuki, Isamu Matsumoto

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Annexin (Anx) V is pivotal in the maintenance of pregnancy by preventing the activation of blood coagulation. The homology of the amino acid sequence between Anx IV and Anx V is highest in Anx family proteins. However, little is known about the roles of Anx IV in pregnancy. The aim of this study is to clarify the roles of circulating Anx IV and Anx V in normal pregnancy. Subjects were non-pregnant women (n = 50), 120 pregnant women, and maternal subjects just after delivery (n = 53) or postpartum (n = 67). Anx IV in the plasma of non-pregnant women was at a concentration 20 times that of Anx V. The plasma levels of Anx IV suddenly increase after delivery, but Anx V levels remain low during this period. Anx IV and Anx V exert similar levels of anticoagulant activity. Anx IV protein was expressed on the basal surface of syncytiotrophoblasts; Anx V protein, on the apical surface of syncytiotrophoblasts. These results suggest that Anx IV enters the maternal bloodstream just after delivery and might play a role in preventing disseminated intravascular coagulopathy, and that Anx V helps to prevent clotting in the placenta during pregnancy.

Original languageEnglish
Pages (from-to)1129-1136
Number of pages8
JournalThrombosis and Haemostasis
Volume91
Issue number6
Publication statusPublished - Jun 2004
Externally publishedYes

Fingerprint

Annexin A4
Annexin A5
Postpartum Period
Pregnant Women
Trophoblasts
Pregnancy
Mothers
Pregnancy Maintenance
Annexins
Amino Acid Sequence Homology
Proteins
Blood Coagulation
Anticoagulants
Placenta

Keywords

  • Annexin
  • Anticoagulant
  • Disseminated intravascular coagulopathy (DIC)
  • Pregnancy

ASJC Scopus subject areas

  • Hematology

Cite this

Masuda, J., Takayama, E., Satoh, A., Ida, M., Shinohara, T., Kojima-Aikawa, K., ... Matsumoto, I. (2004). Levels of annexin IV and V in the plasma of pregnant and postpartum women. Thrombosis and Haemostasis, 91(6), 1129-1136.

Levels of annexin IV and V in the plasma of pregnant and postpartum women. / Masuda, Junko; Takayama, Eiji; Satoh, Ayano; Ida, Michiru; Shinohara, Tadashi; Kojima-Aikawa, Kyoko; Ohsuzu, Fumitaka; Nakanishi, Kuniaki; Kuroda, Koichi; Murakami, Mitsutaka; Suzuki, Kimihiro; Matsumoto, Isamu.

In: Thrombosis and Haemostasis, Vol. 91, No. 6, 06.2004, p. 1129-1136.

Research output: Contribution to journalArticle

Masuda, J, Takayama, E, Satoh, A, Ida, M, Shinohara, T, Kojima-Aikawa, K, Ohsuzu, F, Nakanishi, K, Kuroda, K, Murakami, M, Suzuki, K & Matsumoto, I 2004, 'Levels of annexin IV and V in the plasma of pregnant and postpartum women', Thrombosis and Haemostasis, vol. 91, no. 6, pp. 1129-1136.
Masuda J, Takayama E, Satoh A, Ida M, Shinohara T, Kojima-Aikawa K et al. Levels of annexin IV and V in the plasma of pregnant and postpartum women. Thrombosis and Haemostasis. 2004 Jun;91(6):1129-1136.
Masuda, Junko ; Takayama, Eiji ; Satoh, Ayano ; Ida, Michiru ; Shinohara, Tadashi ; Kojima-Aikawa, Kyoko ; Ohsuzu, Fumitaka ; Nakanishi, Kuniaki ; Kuroda, Koichi ; Murakami, Mitsutaka ; Suzuki, Kimihiro ; Matsumoto, Isamu. / Levels of annexin IV and V in the plasma of pregnant and postpartum women. In: Thrombosis and Haemostasis. 2004 ; Vol. 91, No. 6. pp. 1129-1136.
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