Leukocytoclastic vasculitis associated with immunoglobulin A lambda monoclonal gammopathy of undetermined significance: A case report and review of previously reported cases

Hiroshi Umemura, Osamu Yamasaki, Keiji Iwatsuki

Research output: Contribution to journalArticlepeer-review

Abstract

Leukocytoclastic vasculitis is often associated with immunoglobulin (Ig)A deposition on the vascular walls. IgA-associated leukocytoclastic vasculitis comprises various underlying diseases. Hematological disorders that can be minor triggers include multiple myeloma and monoclonal gammopathy of undetermined significance. Here, we present the case of a 78-year-old woman with leukocytoclastic vasculitis associated with monoclonal gammopathy of undetermined significance of the IgA lambda chain. Oral steroid administration initially showed remission of vasculitis; however, the condition recurred after four attempts of treatment withdrawal. We also reviewed previous reports of 14 cases of IgA-associated leukocytoclastic vasculitis, of which 11 were associated with multiple myeloma and three with monoclonal gammopathy of undetermined significance.

Original languageEnglish
Pages (from-to)1009-1012
Number of pages4
JournalJournal of Dermatology
Volume45
Issue number8
DOIs
Publication statusPublished - Aug 2018

Keywords

  • M-protein gammopathy
  • immunoglobulin A-associated vasculitis
  • leukocytoclastic vasculitis
  • monoclonal gammopathy of undetermined significance
  • myeloma

ASJC Scopus subject areas

  • Dermatology

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