Abstract
Patients with anaplastic large cell lymphoma (ALCL) often present with tumor-mediated skin changes, including pseudocarcinomatous hyperplasia (PCH), acquired ichthyosis, and tissue neutrophilia. We report a 58-year-old male patient with leukocyte common antigen (LCA)-negative, null cell-type ALCL associated with marked PCH mimicking undifferentiated squamous cell carcinoma. Although lymphocyte markers were lacking, the CD30 expression and the clonal rearrangement of the T-cell receptor gamma gene confirmed the diagnosis of ALCL. The patient had an aggressive clinical course, in which the tumor cells metastasized to the regional lymph nodes a few months after surgical removal of the primary lesion, and skin nodules recurred on the face despite intensive polychemotherapy, followed by autologous peripheral blood stem cell transplantation. The diagnosis of ALCL was delayed in our case because of the prominent PCH, the lack of LCA, and the unusually rapid progression of the tumor.
| Original language | English |
|---|---|
| Pages (from-to) | 74-77 |
| Number of pages | 4 |
| Journal | European Journal of Dermatology |
| Volume | 18 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2008 |
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Keywords
- Aggressive
- Anaplastic large cell lymphoma
- CD45
- Leukocyte common antigen
- Pseudocarcinomatous hyperplasia
ASJC Scopus subject areas
- Dermatology
Cite this
Leukocyte common antigen-negative, aggressive cutaneous anaplastic large cell lymphoma with prominent pseudocarcinomatous hyperplasia. / Sugiyama, Hiroko; Asagoe, Kenji; Morizane, Shin; Oono, Takashi; Okazaki, Fusako; Iwatsuki, Keiji.
In: European Journal of Dermatology, Vol. 18, No. 1, 01.2008, p. 74-77.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Leukocyte common antigen-negative, aggressive cutaneous anaplastic large cell lymphoma with prominent pseudocarcinomatous hyperplasia
AU - Sugiyama, Hiroko
AU - Asagoe, Kenji
AU - Morizane, Shin
AU - Oono, Takashi
AU - Okazaki, Fusako
AU - Iwatsuki, Keiji
PY - 2008/1
Y1 - 2008/1
N2 - Patients with anaplastic large cell lymphoma (ALCL) often present with tumor-mediated skin changes, including pseudocarcinomatous hyperplasia (PCH), acquired ichthyosis, and tissue neutrophilia. We report a 58-year-old male patient with leukocyte common antigen (LCA)-negative, null cell-type ALCL associated with marked PCH mimicking undifferentiated squamous cell carcinoma. Although lymphocyte markers were lacking, the CD30 expression and the clonal rearrangement of the T-cell receptor gamma gene confirmed the diagnosis of ALCL. The patient had an aggressive clinical course, in which the tumor cells metastasized to the regional lymph nodes a few months after surgical removal of the primary lesion, and skin nodules recurred on the face despite intensive polychemotherapy, followed by autologous peripheral blood stem cell transplantation. The diagnosis of ALCL was delayed in our case because of the prominent PCH, the lack of LCA, and the unusually rapid progression of the tumor.
AB - Patients with anaplastic large cell lymphoma (ALCL) often present with tumor-mediated skin changes, including pseudocarcinomatous hyperplasia (PCH), acquired ichthyosis, and tissue neutrophilia. We report a 58-year-old male patient with leukocyte common antigen (LCA)-negative, null cell-type ALCL associated with marked PCH mimicking undifferentiated squamous cell carcinoma. Although lymphocyte markers were lacking, the CD30 expression and the clonal rearrangement of the T-cell receptor gamma gene confirmed the diagnosis of ALCL. The patient had an aggressive clinical course, in which the tumor cells metastasized to the regional lymph nodes a few months after surgical removal of the primary lesion, and skin nodules recurred on the face despite intensive polychemotherapy, followed by autologous peripheral blood stem cell transplantation. The diagnosis of ALCL was delayed in our case because of the prominent PCH, the lack of LCA, and the unusually rapid progression of the tumor.
KW - Aggressive
KW - Anaplastic large cell lymphoma
KW - CD45
KW - Leukocyte common antigen
KW - Pseudocarcinomatous hyperplasia
UR - http://www.scopus.com/inward/record.url?scp=38549145971&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=38549145971&partnerID=8YFLogxK
U2 - 10.1684/ejd.2008.0343
DO - 10.1684/ejd.2008.0343
M3 - Article
VL - 18
SP - 74
EP - 77
JO - European Journal of Dermatology
JF - European Journal of Dermatology
SN - 1167-1122
IS - 1
ER -