Leukocyte common antigen-negative, aggressive cutaneous anaplastic large cell lymphoma with prominent pseudocarcinomatous hyperplasia

Hiroko Sugiyama, Kenji Asagoe, Shin Morizane, Takashi Oono, Fusako Okazaki, Keiji Iwatsuki

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Patients with anaplastic large cell lymphoma (ALCL) often present with tumor-mediated skin changes, including pseudocarcinomatous hyperplasia (PCH), acquired ichthyosis, and tissue neutrophilia. We report a 58-year-old male patient with leukocyte common antigen (LCA)-negative, null cell-type ALCL associated with marked PCH mimicking undifferentiated squamous cell carcinoma. Although lymphocyte markers were lacking, the CD30 expression and the clonal rearrangement of the T-cell receptor gamma gene confirmed the diagnosis of ALCL. The patient had an aggressive clinical course, in which the tumor cells metastasized to the regional lymph nodes a few months after surgical removal of the primary lesion, and skin nodules recurred on the face despite intensive polychemotherapy, followed by autologous peripheral blood stem cell transplantation. The diagnosis of ALCL was delayed in our case because of the prominent PCH, the lack of LCA, and the unusually rapid progression of the tumor.

Original languageEnglish
Pages (from-to)74-77
Number of pages4
JournalEuropean Journal of Dermatology
Volume18
Issue number1
DOIs
Publication statusPublished - Jan 2008

Fingerprint

CD45 Antigens
Anaplastic Large-Cell Lymphoma
Hyperplasia
Skin
T-Cell Receptor gamma Genes
Peripheral Blood Stem Cell Transplantation
Null Lymphocytes
Neoplasms
Combination Drug Therapy
Squamous Cell Carcinoma
Lymph Nodes
Lymphocytes

Keywords

  • Aggressive
  • Anaplastic large cell lymphoma
  • CD45
  • Leukocyte common antigen
  • Pseudocarcinomatous hyperplasia

ASJC Scopus subject areas

  • Dermatology

Cite this

Leukocyte common antigen-negative, aggressive cutaneous anaplastic large cell lymphoma with prominent pseudocarcinomatous hyperplasia. / Sugiyama, Hiroko; Asagoe, Kenji; Morizane, Shin; Oono, Takashi; Okazaki, Fusako; Iwatsuki, Keiji.

In: European Journal of Dermatology, Vol. 18, No. 1, 01.2008, p. 74-77.

Research output: Contribution to journalArticle

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AU - Asagoe, Kenji

AU - Morizane, Shin

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AU - Okazaki, Fusako

AU - Iwatsuki, Keiji

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N2 - Patients with anaplastic large cell lymphoma (ALCL) often present with tumor-mediated skin changes, including pseudocarcinomatous hyperplasia (PCH), acquired ichthyosis, and tissue neutrophilia. We report a 58-year-old male patient with leukocyte common antigen (LCA)-negative, null cell-type ALCL associated with marked PCH mimicking undifferentiated squamous cell carcinoma. Although lymphocyte markers were lacking, the CD30 expression and the clonal rearrangement of the T-cell receptor gamma gene confirmed the diagnosis of ALCL. The patient had an aggressive clinical course, in which the tumor cells metastasized to the regional lymph nodes a few months after surgical removal of the primary lesion, and skin nodules recurred on the face despite intensive polychemotherapy, followed by autologous peripheral blood stem cell transplantation. The diagnosis of ALCL was delayed in our case because of the prominent PCH, the lack of LCA, and the unusually rapid progression of the tumor.

AB - Patients with anaplastic large cell lymphoma (ALCL) often present with tumor-mediated skin changes, including pseudocarcinomatous hyperplasia (PCH), acquired ichthyosis, and tissue neutrophilia. We report a 58-year-old male patient with leukocyte common antigen (LCA)-negative, null cell-type ALCL associated with marked PCH mimicking undifferentiated squamous cell carcinoma. Although lymphocyte markers were lacking, the CD30 expression and the clonal rearrangement of the T-cell receptor gamma gene confirmed the diagnosis of ALCL. The patient had an aggressive clinical course, in which the tumor cells metastasized to the regional lymph nodes a few months after surgical removal of the primary lesion, and skin nodules recurred on the face despite intensive polychemotherapy, followed by autologous peripheral blood stem cell transplantation. The diagnosis of ALCL was delayed in our case because of the prominent PCH, the lack of LCA, and the unusually rapid progression of the tumor.

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